N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.0(2,7)]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}methanesulfonamide sodium salt

Base Information

Chemical Name:N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.0(2,7)]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}methanesulfonamide sodium salt
CAS No.:1071519-66-8
Molecular Formula:C₂₅H₂₄FN₄O₆S₂*Na
Molecular Weight:582.609
Hs Code.:

N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.0(2,7)]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}methanesulfonamide sodium salt

Synonyms:N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.0(2,7)]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}methanesulfonamide sodium salt

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Chemical Property of N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.0(2,7)]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}methanesulfonamide sodium salt

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Technology Process of N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.0(2,7)]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}methanesulfonamide sodium salt

There total 26 articles about N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.0(2,7)]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}methanesulfonamide sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1071517-39-9
N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.0(2,7)]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}methanesulfonamide

: 1071519-66-8
N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.0(2,7)]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}methanesulfonamide sodium salt

Guidance literature:: With sodium hydroxide; In ethanol; water;

Reference yield:

: 96-72-0
2-chloro-5-nitrobenzenesulfonamide

: 1071519-66-8
N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.0(2,7)]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}methanesulfonamide sodium salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / acetonitrile / 20 h / 92 °C / Industry scale

2.1: hydrogen / palladium 10% on activated carbon / ethanol; water; tetrahydrofuran / 43 h / 50 °C / 2844.39 Torr / Industry scale

3.1: pyridine / dichloromethane / 0 - 23 °C / Industry scale

4.1: tetrahydrofuran / 1 h / 0 - 23 °C / Industry scale

5.1: sodium hydroxide; water / 30 h / 23 °C / Industry scale

5.2: 0 °C / Industry scale

6.1: 4-methyl-morpholine / acetonitrile / 1 h / 23 °C / Industry scale

6.2: 0 - 23 °C / Industry scale

6.3: 3 h / 50 °C / Industry scale

7.1: sodium hydroxide / ethanol; water / 24 h / 23 °C

With 4-methyl-morpholine; pyridine; water; hydrogen; triethylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 1000313-17-6
2-benzylamino-5-nitro-benzenesulfonamide

: 1071519-66-8
N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.0(2,7)]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}methanesulfonamide sodium salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol; water; tetrahydrofuran / 43 h / 50 °C / 2844.39 Torr / Industry scale

2.1: pyridine / dichloromethane / 0 - 23 °C / Industry scale

3.1: tetrahydrofuran / 1 h / 0 - 23 °C / Industry scale

4.1: sodium hydroxide; water / 30 h / 23 °C / Industry scale

4.2: 0 °C / Industry scale

5.1: 4-methyl-morpholine / acetonitrile / 1 h / 23 °C / Industry scale

5.2: 0 - 23 °C / Industry scale

5.3: 3 h / 50 °C / Industry scale

6.1: sodium hydroxide / ethanol; water / 24 h / 23 °C

With 4-methyl-morpholine; pyridine; water; hydrogen; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;