N-[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]-N-(2-propyn-1-yl)-4-morpholinecarboxamide

Base Information

Chemical Name:N-[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]-N-(2-propyn-1-yl)-4-morpholinecarboxamide
CAS No.:1620482-60-1
Molecular Formula:C₂₇H₃₀N₈O₃
Molecular Weight:514.587
Hs Code.:

Synonyms:N-[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]-N-(2-propyn-1-yl)-4-morpholinecarboxamide

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Chemical Property of N-[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]-N-(2-propyn-1-yl)-4-morpholinecarboxamide

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Technology Process of N-[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]-N-(2-propyn-1-yl)-4-morpholinecarboxamide

There total 4 articles about N-[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]-N-(2-propyn-1-yl)-4-morpholinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 110-91-8,99108-56-2
morpholine

: 1639450-57-9
C₂₃H₂₂ClN₇O₂

: 1620482-60-1
N-[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]-N-(2-propyn-1-yl)-4-morpholinecarboxamide

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 60 ℃; for 0.5h;
DOI:10.1021/ja505517t

Reference yield:

: 1620483-11-5
{4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methanol

: 1620482-60-1
N-[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]-N-(2-propyn-1-yl)-4-morpholinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sulfur trioxide pyridine complex; triethylamine / ethyl acetate; dimethyl sulfoxide / 0.33 h / 0 - 20 °C / Inert atmosphere

2: trimethylsilylazide / methanol / 0 - 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 0 °C

4: N-ethyl-N,N-diisopropylamine; dmap / tetrahydrofuran / 0.5 h / 60 °C

With dmap; trimethylsilylazide; sulfur trioxide pyridine complex; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/ja505517t

Reference yield:

: 1620482-54-3
N-[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]-2-propyn-1-amine

: 1620482-60-1
N-[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]-N-(2-propyn-1-yl)-4-morpholinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 0 °C

2: N-ethyl-N,N-diisopropylamine; dmap / tetrahydrofuran / 0.5 h / 60 °C

With dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1021/ja505517t