5-Isobutyl-1-methoxymethoxy-3-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-3H-pyrazine-2,6-dione

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Chemical Name:5-Isobutyl-1-methoxymethoxy-3-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-3H-pyrazine-2,6-dione
CAS No.:179678-91-2
Molecular Formula:C₁₈H₂₂N₂O₅
Molecular Weight:346.383
Hs Code.:

Synonyms:5-Isobutyl-1-methoxymethoxy-3-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-3H-pyrazine-2,6-dione

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Chemical Property of 5-Isobutyl-1-methoxymethoxy-3-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-3H-pyrazine-2,6-dione

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Technology Process of 5-Isobutyl-1-methoxymethoxy-3-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-3H-pyrazine-2,6-dione

There total 11 articles about 5-Isobutyl-1-methoxymethoxy-3-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-3H-pyrazine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 179678-90-1
(S)-3-Isobutyl-4-(4-methoxy-benzyl)-1-methoxymethoxy-5-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-piperazine-2,6-dione

: N-(4-methoxybenzyl)-4-methyl-2-oxopentanamide

: 179678-91-2
5-Isobutyl-1-methoxymethoxy-3-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-3H-pyrazine-2,6-dione

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water;
DOI:10.1021/jo015665d

Reference yield:

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 179678-91-2
5-Isobutyl-1-methoxymethoxy-3-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-3H-pyrazine-2,6-dione

Guidance literature:: Multi-step reaction with 11 steps

1.1: DIPEA / acetonitrile / 20 - 60 °C

2.1: 101.5 g / DIPEA / acetonitrile / 24 h / 70 °C

3.1: 93.7 percent / TFA / CH₂Cl₂ / 70 h / 20 °C

4.1: TEA; DCC / CH₂Cl₂ / 20 h / 20 °C

5.1: hydroxylamine / ethanol; tetrahydrofuran / 3 h / 20 °C / pH 6.0

6.1: ethanol; H₂O / Heating

7.1: 54 g / DIPEA / CH₂Cl₂ / 2 h / -40 °C

8.1: LHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / 3 h / -78 °C

8.2: 56 percent / 2 h

9.1: DIPEA; DMAP / CH₂Cl₂ / -23 - 20 °C

10.1: 26 percent / DDQ / CH₂Cl₂; H₂O

With dmap; TEA; hydroxylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium hexamethyldisilazane; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jo015665d

Reference yield:

: 179678-66-1
N-(1-tert-butoxy-acet-2-yl)-(S)-leucine methyl ester

: 179678-91-2
5-Isobutyl-1-methoxymethoxy-3-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-3H-pyrazine-2,6-dione

Guidance literature:: Multi-step reaction with 10 steps

1.1: 101.5 g / DIPEA / acetonitrile / 24 h / 70 °C

2.1: 93.7 percent / TFA / CH₂Cl₂ / 70 h / 20 °C

3.1: TEA; DCC / CH₂Cl₂ / 20 h / 20 °C

4.1: hydroxylamine / ethanol; tetrahydrofuran / 3 h / 20 °C / pH 6.0

5.1: ethanol; H₂O / Heating

6.1: 54 g / DIPEA / CH₂Cl₂ / 2 h / -40 °C

7.1: LHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / 3 h / -78 °C

7.2: 56 percent / 2 h

8.1: DIPEA; DMAP / CH₂Cl₂ / -23 - 20 °C

9.1: 26 percent / DDQ / CH₂Cl₂; H₂O

With dmap; TEA; hydroxylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium hexamethyldisilazane; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jo015665d