trans-4-[[3-(5-formyl-1H-1,2,3-benzotriazol-1-yl)propyl](methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate

Base Information

Chemical Name:trans-4-[[3-(5-formyl-1H-1,2,3-benzotriazol-1-yl)propyl](methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate
CAS No.:1435049-24-3
Molecular Formula:C₂₇H₃₀N₄O₄S₂
Molecular Weight:538.692
Hs Code.:

Synonyms:trans-4-[[3-(5-formyl-1H-1,2,3-benzotriazol-1-yl)propyl](methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate

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Chemical Property of trans-4-[[3-(5-formyl-1H-1,2,3-benzotriazol-1-yl)propyl](methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate

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Technology Process of trans-4-[[3-(5-formyl-1H-1,2,3-benzotriazol-1-yl)propyl](methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate

There total 11 articles about trans-4-[[3-(5-formyl-1H-1,2,3-benzotriazol-1-yl)propyl](methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1346762-52-4
trans-4-(methylamino)cyclohexyl hydroxy(di-2-thienyl)acetate

: 1435049-23-2
1-(3-bromopropyl)-1H-1,2,3-benzotriazole-5-carbaldehyde

: 1435049-24-3
trans-4-[[3-(5-formyl-1H-1,2,3-benzotriazol-1-yl)propyl](methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 75 - 90 ℃; for 41h; Inert atmosphere;

Reference yield:

: 400899-99-2
tert-butyl ((1r,4r)-4-hydroxycyclohexyl)(methyl)carbamate

: 1435049-24-3
trans-4-[[3-(5-formyl-1H-1,2,3-benzotriazol-1-yl)propyl](methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / toluene; mineral oil / 1.5 h / 155 °C

2.1: hydrogenchloride / 1,4-dioxane / 24 h / 20 °C

2.2: pH 8-9

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 41 h / 75 - 90 °C / Inert atmosphere

With hydrogenchloride; sodium hydride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; toluene; acetonitrile; mineral oil;

Reference yield:

: 111300-06-2
trans-tert-butyl 4-hydroxycyclohexylcarbamate

: 1435049-24-3
trans-4-[[3-(5-formyl-1H-1,2,3-benzotriazol-1-yl)propyl](methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / Reflux

2.1: acetonitrile / 20 °C

3.1: sodium hydride / toluene; mineral oil / 1.5 h / 155 °C

4.1: hydrogenchloride / 1,4-dioxane / 24 h / 20 °C

4.2: pH 8-9

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 41 h / 75 - 90 °C / Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; toluene; acetonitrile; mineral oil;