(2Z)-4-Acetyloxy-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]but-2-enoic acid

Base Information

• Chemical Name: (2Z)-4-Acetyloxy-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]but-2-enoic acid
• CAS No.: 179174-94-8
• Molecular Formula: C₁₉H₁₇FO₆S
• Molecular Weight: 392.405

Synonyms:(2Z)-4-Acetyloxy-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]but-2-enoic acid

Chemical Property of (2Z)-4-Acetyloxy-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]but-2-enoic acid

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Technology Process of (2Z)-4-Acetyloxy-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]but-2-enoic acid

There total 1 articles about (2Z)-4-Acetyloxy-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]but-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

2-methyl-but-2-ene (513-35-9) + (2Z)-3-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-4oxobut-2-enyl acetate (179174-93-7) → (2Z)-4-Acetyloxy-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]but-2-enoic acid (179174-94-8)

Guidance literature:

With sodium dihydrogenphosphate; NaClO₂; In water; tert-butyl alcohol;

Reference yield: 83.0%

(2Z)-4-Acetyloxy-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]but-2-enoic acid (179174-94-8) + 2-mercapto-2-methyl-1-propylamine (7684-18-6) + bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride (68641-49-6) → (2Z)-3-(4-Fluorophenyl)-3-[N-methyl-N-[2-methyl-2-sulfanylpropyl]carbamoyl]-2-[4-(methylsulfonyl)phenyl]prop-2-enyl acetate

Guidance literature:

With dmap; triethylamine; In tetrahydrofuran;

Reference yield:

(2Z)-4-Acetyloxy-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]but-2-enoic acid (179174-94-8) + bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride (68641-49-6) → 3-{4-[1-Methyl-1-(nitrosothio)ethyl]-2-oxo-1,3-oxazolidin-3-yl}propyl (2Z)-4-acetyloxy-2-(4-flurophenyl)-3-[4-(methylsulfonyl)phenyl]but-2-enoate (346683-81-6)

Guidance literature:

With dmap; In tetrahydrofuran;

upstream raw materials:

2-methyl-but-2-ene

(2Z)-3-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-4oxobut-2-enyl acetate

Downstream raw materials:

3-{4-[1-Methyl-1-(nitrosothio)ethyl]-2-oxo-1,3-oxazolidin-3-yl}propyl (2Z)-4-acetyloxy-2-(4-flurophenyl)-3-[4-(methylsulfonyl)phenyl]but-2-enoate

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