4-(N-(2,4-dimethoxybenzyl)-4-(4-(N-(2,4-dimethoxybenzyl)-4-aminobenzamido)benzamido)benzamido)benzoic acid

Base Information

• Chemical Name: 4-(N-(2,4-dimethoxybenzyl)-4-(4-(N-(2,4-dimethoxybenzyl)-4-aminobenzamido)benzamido)benzamido)benzoic acid
• CAS No.: 943249-95-4
• Molecular Formula: C₄₆H₄₂N₄O₉
• Molecular Weight: 794.861
• Mol file: 943249-95-4.mol

Synonyms:4-(N-(2,4-dimethoxybenzyl)-4-(4-(N-(2,4-dimethoxybenzyl)-4-aminobenzamido)benzamido)benzamido)benzoic acid

Chemical Property of 4-(N-(2,4-dimethoxybenzyl)-4-(4-(N-(2,4-dimethoxybenzyl)-4-aminobenzamido)benzamido)benzamido)benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(N-(2,4-dimethoxybenzyl)-4-(4-(N-(2,4-dimethoxybenzyl)-4-aminobenzamido)benzamido)benzamido)benzoic acid

There total 8 articles about 4-(N-(2,4-dimethoxybenzyl)-4-(4-(N-(2,4-dimethoxybenzyl)-4-aminobenzamido)benzamido)benzamido)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-(N-(2,4-dimethoxybenzyl)-4-(4-(N-(2,4-dimethoxybenzyl)-4-nitrobenzamido)benzamido)benzamido)benzoic acid (943249-94-3) → 4-(N-(2,4-dimethoxybenzyl)-4-(4-(N-(2,4-dimethoxybenzyl)-4-aminobenzamido)benzamido)benzamido)benzoic acid (943249-95-4)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; methanol; for 130h; cooling;

DOI:10.1039/b617598h

Reference yield:

C16H15NO4 → 4-(N-(2,4-dimethoxybenzyl)-4-(4-(N-(2,4-dimethoxybenzyl)-4-aminobenzamido)benzamido)benzamido)benzoic acid (943249-95-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 83.32 g / NaBH₄ / tetrahydrofuran / 72 h / cooling

2: 82 percent / 1-methyl-pyrrolidin-2-one / 48 h / 20 °C

3: thionyl chloride / 1-methyl-pyrrolidin-2-one / 2 h / 20 °C

4: 12.35 g / 1-methyl-pyrrolidin-2-one / 12 h / 20 °C

5: 90 percent / ammonium formate / Pd/C / 1-methyl-pyrrolidin-2-one; methanol / 130 h / cooling

With sodium tetrahydroborate; thionyl chloride; ammonium formate; palladium on activated charcoal; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol;

DOI:10.1039/b617598h

Reference yield:

N-(2,4-dimethoxybenzyl)-4-(4-nitrobenzamido)benzoic acid (943249-91-0) → 4-(N-(2,4-dimethoxybenzyl)-4-(4-(N-(2,4-dimethoxybenzyl)-4-aminobenzamido)benzamido)benzamido)benzoic acid (943249-95-4)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 1-methyl-pyrrolidin-2-one / 2 h / 20 °C

2: 12.35 g / 1-methyl-pyrrolidin-2-one / 12 h / 20 °C

3: 90 percent / ammonium formate / Pd/C / 1-methyl-pyrrolidin-2-one; methanol / 130 h / cooling

With thionyl chloride; ammonium formate; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; methanol;

DOI:10.1039/b617598h

upstream raw materials:

4-(N-(2,4-dimethoxybenzyl)-4-(4-(N-(2,4-dimethoxybenzyl)-4-nitrobenzamido)benzamido)benzamido)benzoic acid

N-(2,4-dimethoxybenzyl)-4-(4-nitrobenzamido)benzoic acid

N-(2,4-dimethoxybenzyl)-4-(4-nitrobenzamido)benzoic acid chloride

N-(2,4-dimethoxybenzyl)-4-(4-aminobenzamido)benzoic acid