(5R,8R,9S,11R,13aS)-5-benzyl-9-(tert-butyldimethylsilyloxy)-8-methyl-11-((S)-1-methyl-6-oxoheptyl)-decahydro-12-oxa-3a,6-diazacyclopentacyclododecene-4,7,13-trione

Base Information

Chemical Name:(5R,8R,9S,11R,13aS)-5-benzyl-9-(tert-butyldimethylsilyloxy)-8-methyl-11-((S)-1-methyl-6-oxoheptyl)-decahydro-12-oxa-3a,6-diazacyclopentacyclododecene-4,7,13-trione
CAS No.:1258866-18-0
Molecular Formula:C₃₄H₅₄N₂O₆Si
Molecular Weight:614.898
Hs Code.:

(5R,8R,9S,11R,13aS)-5-benzyl-9-(tert-butyldimethylsilyloxy)-8-methyl-11-((S)-1-methyl-6-oxoheptyl)-decahydro-12-oxa-3a,6-diazacyclopentacyclododecene-4,7,13-trione

Synonyms:(5R,8R,9S,11R,13aS)-5-benzyl-9-(tert-butyldimethylsilyloxy)-8-methyl-11-((S)-1-methyl-6-oxoheptyl)-decahydro-12-oxa-3a,6-diazacyclopentacyclododecene-4,7,13-trione

Suppliers and Price of (5R,8R,9S,11R,13aS)-5-benzyl-9-(tert-butyldimethylsilyloxy)-8-methyl-11-((S)-1-methyl-6-oxoheptyl)-decahydro-12-oxa-3a,6-diazacyclopentacyclododecene-4,7,13-trione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (5R,8R,9S,11R,13aS)-5-benzyl-9-(tert-butyldimethylsilyloxy)-8-methyl-11-((S)-1-methyl-6-oxoheptyl)-decahydro-12-oxa-3a,6-diazacyclopentacyclododecene-4,7,13-trione

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (5R,8R,9S,11R,13aS)-5-benzyl-9-(tert-butyldimethylsilyloxy)-8-methyl-11-((S)-1-methyl-6-oxoheptyl)-decahydro-12-oxa-3a,6-diazacyclopentacyclododecene-4,7,13-trione

There total 15 articles about (5R,8R,9S,11R,13aS)-5-benzyl-9-(tert-butyldimethylsilyloxy)-8-methyl-11-((S)-1-methyl-6-oxoheptyl)-decahydro-12-oxa-3a,6-diazacyclopentacyclododecene-4,7,13-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₄H₅₆N₂O₇Si

: 1258866-18-0
(5R,8R,9S,11R,13aS)-5-benzyl-9-(tert-butyldimethylsilyloxy)-8-methyl-11-((S)-1-methyl-6-oxoheptyl)-decahydro-12-oxa-3a,6-diazacyclopentacyclododecene-4,7,13-trione

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jo1017487

Reference yield:

: 1258866-19-1
(5S,6S)-5-allyl-2,2,3,3,6,9,9,10,10-nonamethyl-4,8-dioxa-3,9-disilaundecane

: 1258866-18-0
(5R,8R,9S,11R,13aS)-5-benzyl-9-(tert-butyldimethylsilyloxy)-8-methyl-11-((S)-1-methyl-6-oxoheptyl)-decahydro-12-oxa-3a,6-diazacyclopentacyclododecene-4,7,13-trione

Guidance literature:: Multi-step reaction with 10 steps

1: 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide / 1,4-dioxane; water / 3.5 h / 20 °C / Inert atmosphere

2: diethyl ether / 4 h / -78 °C / Inert atmosphere

3: Hoveyda-Grubbs catalyst second generation / dichloromethane / 24 h / Reflux; Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C / 760.05 Torr / Inert atmosphere

5: dmap; 2,4,6-trichlorobenzoyl chloride; N-ethyl-N,N-diisopropylamine / toluene / 8 h / -78 - 20 °C / Inert atmosphere

6: water; tin(ll) chloride / ethanol / 2 h / 20 °C / Inert atmosphere

7: sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide / dichloromethane; water / 0.5 h / 0 °C / Inert atmosphere

8: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; tert-butyl alcohol / 0.5 h / 0 - 20 °C / Inert atmosphere

9: diethylamine / acetonitrile / 20 °C / Inert atmosphere

10: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; dmap; sodium hypochlorite; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; Hoveyda-Grubbs catalyst second generation; 2-methyl-but-2-ene; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; 2,4,6-trichlorobenzoyl chloride; palladium 10% on activated carbon; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; potassium bromide; In 1,4-dioxane; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; toluene; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jo1017487

Reference yield:

: 1258866-10-2
(3S,4R,6S,7S)-6,8-bis-(tert-butyldimethylsilyloxy)-3,7-dimethyloct-1-en-4-ol

: 1258866-18-0
(5R,8R,9S,11R,13aS)-5-benzyl-9-(tert-butyldimethylsilyloxy)-8-methyl-11-((S)-1-methyl-6-oxoheptyl)-decahydro-12-oxa-3a,6-diazacyclopentacyclododecene-4,7,13-trione

Guidance literature:: Multi-step reaction with 8 steps

1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 24 h / Reflux; Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C / 760.05 Torr / Inert atmosphere

3: dmap; 2,4,6-trichlorobenzoyl chloride; N-ethyl-N,N-diisopropylamine / toluene / 8 h / -78 - 20 °C / Inert atmosphere

4: water; tin(ll) chloride / ethanol / 2 h / 20 °C / Inert atmosphere

5: sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide / dichloromethane; water / 0.5 h / 0 °C / Inert atmosphere

6: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; tert-butyl alcohol / 0.5 h / 0 - 20 °C / Inert atmosphere

7: diethylamine / acetonitrile / 20 °C / Inert atmosphere

8: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With dmap; sodium hypochlorite; sodium chlorite; sodium dihydrogenphosphate; Hoveyda-Grubbs catalyst second generation; 2-methyl-but-2-ene; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; 2,4,6-trichlorobenzoyl chloride; palladium 10% on activated carbon; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; potassium bromide; In ethanol; dichloromethane; water; ethyl acetate; toluene; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jo1017487