N-(tert-butyloxycarbonyl)-L-tyrosyl-D-arginine hydrochloride

Base Information

• Chemical Name: N-(tert-butyloxycarbonyl)-L-tyrosyl-D-arginine hydrochloride
• CAS No.: 88331-11-7
• Molecular Formula: C₂₀H₃₁N₅O₆*ClH
• Molecular Weight: 473.957
• Mol file: 88331-11-7.mol

Synonyms:N-(tert-butyloxycarbonyl)-L-tyrosyl-D-arginine hydrochloride

Chemical Property of N-(tert-butyloxycarbonyl)-L-tyrosyl-D-arginine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(tert-butyloxycarbonyl)-L-tyrosyl-D-arginine hydrochloride

There total 3 articles about N-(tert-butyloxycarbonyl)-L-tyrosyl-D-arginine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

Boc-Tyr-D-Arg-OMe (88331-10-6) → N-(tert-butyloxycarbonyl)-L-tyrosyl-D-arginine hydrochloride (88331-11-7)

Guidance literature:

With sodium hydroxide; In methanol; water; at 23 ℃; for 1h;

DOI:10.1021/jm00400a012

Reference yield:

Boc-Tyr-OH (3978-80-1) → N-(tert-butyloxycarbonyl)-L-tyrosyl-D-arginine hydrochloride (88331-11-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NMM, isobutyl chloroformate, 2.) NMM / 1.) THF, -15 deg C, 2.5 min, 2.) DMF, H₂O, -15 deg C, 2.5 h

2: 77 percent / NaOH / methanol; H₂O / 1 h / 23 °C

With 4-methyl-morpholine; sodium hydroxide; isobutyl chloroformate; In methanol; water;

DOI:10.1021/jm00400a012

Reference yield:

methyl (2R)-2-amino-5-carbamimidamidopentanoate dihydrochloride (22888-59-1,26340-89-6,78851-84-0,111237-99-1,18598-71-5) → N-(tert-butyloxycarbonyl)-L-tyrosyl-D-arginine hydrochloride (88331-11-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NMM, isobutyl chloroformate, 2.) NMM / 1.) THF, -15 deg C, 2.5 min, 2.) DMF, H₂O, -15 deg C, 2.5 h

2: 77 percent / NaOH / methanol; H₂O / 1 h / 23 °C

With 4-methyl-morpholine; sodium hydroxide; isobutyl chloroformate; In methanol; water;

DOI:10.1021/jm00400a012

upstream raw materials:

Boc-Tyr-D-Arg-OMe

Boc-Tyr-OH

methyl (2R)-2-amino-5-carbamimidamidopentanoate dihydrochloride

Downstream raw materials:

N¹-Ethyl-N¹-(N-tert-butyloxycarbonyl-L-tyrosyl-D-arginylglycyl)-L-4-nitrophenylalaninamide

[(S)-1-[(R)-1-({[(S)-2-((S)-2-Carbamoyl-pyrrolidin-1-yl)-1-(4-nitro-benzyl)-2-oxo-ethylcarbamoyl]-methyl}-carbamoyl)-4-guanidino-butylcarbamoyl]-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

N¹-amidino-L-tyrosyl-D-arginylglycyl-L-4-nitrophenylalanyl-L-prolinamide diacetate

L-tyrosyl-D-arginylglycyl-L-4-nitrophenylalanyl-L-prolinamide diacetate