benzyl (2R,4S)-4-(4-tert-butoxy-4-oxobutyl)-4-methyl-5-oxo-2-phenyloxazolidine-3carboxylate

Base Information

• Chemical Name: benzyl (2R,4S)-4-(4-tert-butoxy-4-oxobutyl)-4-methyl-5-oxo-2-phenyloxazolidine-3carboxylate
• CAS No.: 1072845-46-5
• Molecular Formula: C₂₆H₃₁NO₆
• Molecular Weight: 453.535
• Mol file: 1072845-46-5.mol

Synonyms:benzyl (2R,4S)-4-(4-tert-butoxy-4-oxobutyl)-4-methyl-5-oxo-2-phenyloxazolidine-3carboxylate

Chemical Property of benzyl (2R,4S)-4-(4-tert-butoxy-4-oxobutyl)-4-methyl-5-oxo-2-phenyloxazolidine-3carboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of benzyl (2R,4S)-4-(4-tert-butoxy-4-oxobutyl)-4-methyl-5-oxo-2-phenyloxazolidine-3carboxylate

There total 1 articles about benzyl (2R,4S)-4-(4-tert-butoxy-4-oxobutyl)-4-methyl-5-oxo-2-phenyloxazolidine-3carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

tert-butyl 4-iodobutanoate (6182-78-1) + (2R,4S)-3-<(Benzyloxy)carbonyl>-4-methyl-2-phenyl-1,3-oxazolidin-5-one (135923-86-3) → benzyl (2R,4S)-4-(4-tert-butoxy-4-oxobutyl)-4-methyl-5-oxo-2-phenyloxazolidine-3carboxylate (1072845-46-5)

Guidance literature:

(2R,4S)-3-<(Benzyloxy)carbonyl>-4-methyl-2-phenyl-1,3-oxazolidin-5-one; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

tert-butyl 4-iodobutanoate; In tetrahydrofuran; at -78 - 20 ℃; stereoselective reaction;

DOI:10.1021/jm800487r

Reference yield: 76.1%

benzyl (2R,4S)-4-(4-tert-butoxy-4-oxobutyl)-4-methyl-5-oxo-2-phenyloxazolidine-3carboxylate (1072845-46-5) → (S)-2-(benzyloxycarbonylamino)-6-tert-butoxy-2-methyl-6-oxohexanoic acid (1072845-53-4)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 0 - 25 ℃;

DOI:10.1021/jm800487r

upstream raw materials:

tert-butyl 4-iodobutanoate

(2R,4S)-3-<(Benzyloxy)carbonyl>-4-methyl-2-phenyl-1,3-oxazolidin-5-one

Downstream raw materials:

(S)-2-(benzyloxycarbonylamino)-6-tert-butoxy-2-methyl-6-oxohexanoic acid