ethyl 1-{4-[2-({[2'-chloro-3-methyl-4'-(trifluoromethyl)-4-biphenylyl]methyl}oxy)-5-methylphenyl]-1,3-thiazol-2-yl}-4-piperidinecarboxylate

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Chemical Name:ethyl 1-{4-[2-({[2'-chloro-3-methyl-4'-(trifluoromethyl)-4-biphenylyl]methyl}oxy)-5-methylphenyl]-1,3-thiazol-2-yl}-4-piperidinecarboxylate
CAS No.:1207618-15-2
Molecular Formula:C₃₃H₃₂ClF₃N₂O₃S
Molecular Weight:629.143
Hs Code.:

Synonyms:ethyl 1-{4-[2-({[2'-chloro-3-methyl-4'-(trifluoromethyl)-4-biphenylyl]methyl}oxy)-5-methylphenyl]-1,3-thiazol-2-yl}-4-piperidinecarboxylate

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Chemical Property of ethyl 1-{4-[2-({[2'-chloro-3-methyl-4'-(trifluoromethyl)-4-biphenylyl]methyl}oxy)-5-methylphenyl]-1,3-thiazol-2-yl}-4-piperidinecarboxylate

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Technology Process of ethyl 1-{4-[2-({[2'-chloro-3-methyl-4'-(trifluoromethyl)-4-biphenylyl]methyl}oxy)-5-methylphenyl]-1,3-thiazol-2-yl}-4-piperidinecarboxylate

There total 1 articles about ethyl 1-{4-[2-({[2'-chloro-3-methyl-4'-(trifluoromethyl)-4-biphenylyl]methyl}oxy)-5-methylphenyl]-1,3-thiazol-2-yl}-4-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.2%

: 1207618-13-0
ethyl 1-[4-(2-{[(4-bromo-2-methylphenyl)methyl]oxy}-5-methylphenyl)-1,3-thiazol-2-yl]-4-piperidinecarboxylate

: (2-chloro-4-(trifluoromethyl)phenyl)boronic acid

: 1207618-15-2
ethyl 1-{4-[2-({[2'-chloro-3-methyl-4'-(trifluoromethyl)-4-biphenylyl]methyl}oxy)-5-methylphenyl]-1,3-thiazol-2-yl}-4-piperidinecarboxylate

Guidance literature:: With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 120 ℃; for 0.333333h; Sealed tube;

Reference yield: 43.9%

: 1207618-15-2
ethyl 1-{4-[2-({[2'-chloro-3-methyl-4'-(trifluoromethyl)-4-biphenylyl]methyl}oxy)-5-methylphenyl]-1,3-thiazol-2-yl}-4-piperidinecarboxylate

: 1207617-15-9
1-{4-[2-({[2'-chloro-3-methyl-4'-(trifluoromethyl)-4-biphenylyl]methyl}oxy)-5-methylphenyl]-1,3-thiazol-2-yl}-4-piperidinecarboxylic acid

Guidance literature:: ethyl 1-{4-[2-({[2'-chloro-3-methyl-4'-(trifluoromethyl)-4-biphenylyl]methyl}oxy)-5-methylphenyl]-1,3-thiazol-2-yl}-4-piperidinecarboxylate; With water; sodium hydroxide; In ethanol; at 90 ℃; for 2h;

With hydrogenchloride; In water; pH=5;