(S)-N-(4-bromobenzyl)-N,N,4-trimethyl-2-(1-methyl-3-(4-nitrophenyl)thioureido)-pentan-1-ammonium bromide

Base Information

• Chemical Name: (S)-N-(4-bromobenzyl)-N,N,4-trimethyl-2-(1-methyl-3-(4-nitrophenyl)thioureido)-pentan-1-ammonium bromide
• CAS No.: 1438263-90-1
• Molecular Formula: Br*C₂₃H₃₂BrN₄O₂S
• Molecular Weight: 588.407
• Mol file: 1438263-90-1.mol

Synonyms:(S)-N-(4-bromobenzyl)-N,N,4-trimethyl-2-(1-methyl-3-(4-nitrophenyl)thioureido)-pentan-1-ammonium bromide

Chemical Property of (S)-N-(4-bromobenzyl)-N,N,4-trimethyl-2-(1-methyl-3-(4-nitrophenyl)thioureido)-pentan-1-ammonium bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-(4-bromobenzyl)-N,N,4-trimethyl-2-(1-methyl-3-(4-nitrophenyl)thioureido)-pentan-1-ammonium bromide

There total 4 articles about (S)-N-(4-bromobenzyl)-N,N,4-trimethyl-2-(1-methyl-3-(4-nitrophenyl)thioureido)-pentan-1-ammonium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H26N4O2S + 1-bromomethyl-4-bromobenzene (589-15-1) → (S)-N-(4-bromobenzyl)-N,N,4-trimethyl-2-(1-methyl-3-(4-nitrophenyl)thioureido)-pentan-1-ammonium bromide (1438263-90-1)

Guidance literature:

In acetonitrile; at 20 ℃;

DOI:10.1016/j.tet.2013.04.079

Reference yield:

C14H28N2O3 → (S)-N-(4-bromobenzyl)-N,N,4-trimethyl-2-(1-methyl-3-(4-nitrophenyl)thioureido)-pentan-1-ammonium bromide (1438263-90-1)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 0 - 75 °C

2: dichloromethane

3: acetonitrile / 20 °C

With lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1016/j.tet.2013.04.079

Reference yield:

N-t-butoxycarbonyl-N-methyl-L-leucine (53363-89-6) → (S)-N-(4-bromobenzyl)-N,N,4-trimethyl-2-(1-methyl-3-(4-nitrophenyl)thioureido)-pentan-1-ammonium bromide (1438263-90-1)

Guidance literature:

Multi-step reaction with 4 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 0 - 75 °C

3: dichloromethane

4: acetonitrile / 20 °C

With lithium aluminium tetrahydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1016/j.tet.2013.04.079

upstream raw materials:

1-bromomethyl-4-bromobenzene

N-t-butoxycarbonyl-N-methyl-L-leucine