Diisopropyl-phosphoramidous acid 6-(4-{6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexylcarbamoyl}-benzoylamino)-hexyl ester 2-cyano-ethyl ester

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Chemical Name:Diisopropyl-phosphoramidous acid 6-(4-{6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexylcarbamoyl}-benzoylamino)-hexyl ester 2-cyano-ethyl ester
CAS No.:144002-84-6
Molecular Formula:C₅₀H₆₇N₄O₇P
Molecular Weight:867.078
Hs Code.:

Diisopropyl-phosphoramidous acid 6-(4-{6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexylcarbamoyl}-benzoylamino)-hexyl ester 2-cyano-ethyl ester

Synonyms:Diisopropyl-phosphoramidous acid 6-(4-{6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexylcarbamoyl}-benzoylamino)-hexyl ester 2-cyano-ethyl ester

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Chemical Property of Diisopropyl-phosphoramidous acid 6-(4-{6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexylcarbamoyl}-benzoylamino)-hexyl ester 2-cyano-ethyl ester

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Technology Process of Diisopropyl-phosphoramidous acid 6-(4-{6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexylcarbamoyl}-benzoylamino)-hexyl ester 2-cyano-ethyl ester

There total 7 articles about Diisopropyl-phosphoramidous acid 6-(4-{6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexylcarbamoyl}-benzoylamino)-hexyl ester 2-cyano-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 144002-82-4
N-<6-((4,4'-dimethoxytrityl)oxy)hexyl>-N'-(6-hydroxyhexyl)terephthalamide

: 144002-84-6
Diisopropyl-phosphoramidous acid 6-(4-{6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexylcarbamoyl}-benzoylamino)-hexyl ester 2-cyano-ethyl ester

Guidance literature:: With dmap; diisopropylamine; In tetrahydrofuran; for 4h;
DOI:10.1021/ja00049a003

Reference yield:

: 4048-33-3
6-amino-1-hexanol

: 144002-84-6
Diisopropyl-phosphoramidous acid 6-(4-{6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexylcarbamoyl}-benzoylamino)-hexyl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 11.2 g / imidazole / dimethylformamide / Ambient temperature

2: 0.704 g / K₂CO₃ / benzene; diethyl ether; H₂O

3: 40 percent / Bu₄NF / tetrahydrofuran / 1 h

4: 65 percent / pyridine, 4-(dimethylamino)pyridine

5: 98 percent / Bu₄NF / tetrahydrofuran / 3 h

6: 60 percent / diisopropylamine, 4-(dimethylamino)pyridine / tetrahydrofuran / 4 h

With pyridine; 1H-imidazole; dmap; tetrabutyl ammonium fluoride; potassium carbonate; diisopropylamine; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja00049a003

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 144002-84-6
Diisopropyl-phosphoramidous acid 6-(4-{6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexylcarbamoyl}-benzoylamino)-hexyl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / pyridine, 4-(dimethylamino)pyridine

2: 98 percent / Bu₄NF / tetrahydrofuran / 3 h

3: 60 percent / diisopropylamine, 4-(dimethylamino)pyridine / tetrahydrofuran / 4 h

With pyridine; dmap; tetrabutyl ammonium fluoride; diisopropylamine; In tetrahydrofuran;
DOI:10.1021/ja00049a003