2-[Bis(phenylmethyl)amino]-1-(4-fluorophenyl)-1-propanone

Base Information

Chemical Name:2-[Bis(phenylmethyl)amino]-1-(4-fluorophenyl)-1-propanone
CAS No.:211242-52-3
Molecular Formula:C₂₃H₂₂FNO
Molecular Weight:347.432
Hs Code.:
DSSTox Substance ID:DTXSID201195068

Synonyms:DTXSID201195068;2-[Bis(phenylmethyl)amino]-1-(4-fluorophenyl)-1-propanone;211242-52-3

Suppliers and Price of 2-[Bis(phenylmethyl)amino]-1-(4-fluorophenyl)-1-propanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[Bis(phenylmethyl)amino]-1-(4-fluorophenyl)-1-propanone

Chemical Property:

XLogP3:5.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:347.16854249
Heavy Atom Count:26
Complexity:400

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C(=O)C1=CC=C(C=C1)F)N(CC2=CC=CC=C2)CC3=CC=CC=C3

Technology Process of 2-[Bis(phenylmethyl)amino]-1-(4-fluorophenyl)-1-propanone

There total 2 articles about 2-[Bis(phenylmethyl)amino]-1-(4-fluorophenyl)-1-propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 345-94-8
2-bromo-1-(4-fluorophenyl)propan-1-one

: 103-49-1
dibenzylamine

: 211242-52-3
2-N,N-dibenzylamino-1-(4-fluorophenyl)-1-propanone

Guidance literature:: With sodium carbonate; In acetonitrile; at 60 ℃;
DOI:10.1021/acs.jmedchem.7b01210

Reference yield:

: 456-03-1
1-(4-fluorophenyl)propan-1-one

: 211242-52-3
2-N,N-dibenzylamino-1-(4-fluorophenyl)-1-propanone

Guidance literature:: Multi-step reaction with 2 steps

1: bromine / CCl₄ / 2 h

2: 85 percent / acetonitrile / 60 °C

With bromine; In tetrachloromethane; acetonitrile; 1: Bromination / 2: Alkylation;
DOI:10.1002/1099-1344(200012)43:14<1345::AID-JLCR424>3.0.CO;2-N