(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-3,5-dimethyl-benzoylamino}-pentanedioic acid diethyl ester

Base Information

Chemical Name:(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-3,5-dimethyl-benzoylamino}-pentanedioic acid diethyl ester
CAS No.:153304-32-6
Molecular Formula:C₂₆H₃₄N₈O₅
Molecular Weight:538.607
Hs Code.:

Synonyms:(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-3,5-dimethyl-benzoylamino}-pentanedioic acid diethyl ester

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Chemical Property of (S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-3,5-dimethyl-benzoylamino}-pentanedioic acid diethyl ester

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Technology Process of (S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-3,5-dimethyl-benzoylamino}-pentanedioic acid diethyl ester

There total 8 articles about (S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-3,5-dimethyl-benzoylamino}-pentanedioic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 52853-40-4
6-bromomethyl-2,4-diaminopteridine hydrobromide

: 153304-63-3
(S)-2-(3,5-Dimethyl-4-methylamino-benzoylamino)-pentanedioic acid diethyl ester

: 153304-32-6
(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-3,5-dimethyl-benzoylamino}-pentanedioic acid diethyl ester

Guidance literature:: In N,N-dimethyl acetamide; at 55 - 65 ℃; for 4h;
DOI:10.1248/cpb.44.2287

Reference yield:

: 3095-47-4
4-amino-3,5-dimethylbenzoic acid ethyl ester

: 153304-32-6
(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-3,5-dimethyl-benzoylamino}-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / NaH / tetrahydrofuran / Ambient temperature

2: 1.) NaH / 1.) 15 min, 2.) RT, overnight

3: 99 percent / 2N aq. NaOH / ethanol / 2 h / Heating

4: SOCl₂, DMF / 2 h / Ambient temperature

5: K₂CO₃ / CH₂Cl₂; H₂O / 12 h / Ambient temperature

6: 77 percent / HBr, CH₃COOH, anisole / 4 h / Ambient temperature

7: 40 percent / N,N-dimethyl-acetamide / 4 h / 55 - 65 °C

With sodium hydroxide; thionyl chloride; hydrogen bromide; sodium hydride; potassium carbonate; acetic acid; methoxybenzene; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water;
DOI:10.1248/cpb.44.2287

Reference yield:

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 153304-32-6
(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-3,5-dimethyl-benzoylamino}-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / CH₂Cl₂; H₂O / 12 h / Ambient temperature

2: 77 percent / HBr, CH₃COOH, anisole / 4 h / Ambient temperature

3: 40 percent / N,N-dimethyl-acetamide / 4 h / 55 - 65 °C

With hydrogen bromide; potassium carbonate; acetic acid; methoxybenzene; In dichloromethane; N,N-dimethyl acetamide; water;
DOI:10.1248/cpb.44.2287