2,2-Dimethyl-propionic acid (E)-(1S,3R)-3-(tert-butyl-dimethyl-silanyloxy)-6-methyl-1-(2-oxo-ethyl)-8-phenyl-oct-6-enyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (E)-(1S,3R)-3-(tert-butyl-dimethyl-silanyloxy)-6-methyl-1-(2-oxo-ethyl)-8-phenyl-oct-6-enyl ester
CAS No.:883907-97-9
Molecular Formula:C₂₈H₄₆O₄Si
Molecular Weight:474.756
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid (E)-(1S,3R)-3-(tert-butyl-dimethyl-silanyloxy)-6-methyl-1-(2-oxo-ethyl)-8-phenyl-oct-6-enyl ester

Suppliers and Price of 2,2-Dimethyl-propionic acid (E)-(1S,3R)-3-(tert-butyl-dimethyl-silanyloxy)-6-methyl-1-(2-oxo-ethyl)-8-phenyl-oct-6-enyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2,2-Dimethyl-propionic acid (E)-(1S,3R)-3-(tert-butyl-dimethyl-silanyloxy)-6-methyl-1-(2-oxo-ethyl)-8-phenyl-oct-6-enyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2,2-Dimethyl-propionic acid (E)-(1S,3R)-3-(tert-butyl-dimethyl-silanyloxy)-6-methyl-1-(2-oxo-ethyl)-8-phenyl-oct-6-enyl ester

There total 11 articles about 2,2-Dimethyl-propionic acid (E)-(1S,3R)-3-(tert-butyl-dimethyl-silanyloxy)-6-methyl-1-(2-oxo-ethyl)-8-phenyl-oct-6-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2,2-Dimethyl-propionic acid (E)-(1S,3R)-3-(tert-butyl-dimethyl-silanyloxy)-1-[2-((S)-4-isopropyl-2-thioxo-thiazolidin-3-yl)-2-oxo-ethyl]-6-methyl-8-phenyl-oct-6-enyl ester

: 883907-97-9
2,2-Dimethyl-propionic acid (E)-(1S,3R)-3-(tert-butyl-dimethyl-silanyloxy)-6-methyl-1-(2-oxo-ethyl)-8-phenyl-oct-6-enyl ester

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; at -78 ℃;
DOI:10.1055/s-2006-926263

Reference yield:

: 5390-04-5
pent-1-yn-5-ol

: 883907-97-9
2,2-Dimethyl-propionic acid (E)-(1S,3R)-3-(tert-butyl-dimethyl-silanyloxy)-6-methyl-1-(2-oxo-ethyl)-8-phenyl-oct-6-enyl ester

Guidance literature:: Multi-step reaction with 11 steps

1.1: imidazole / dimethylformamide

2.1: aq. Cp₂ZrCl₂ / CH₂Cl₂ / 4 h / -23 °C

2.2: I₂ / tetrahydrofuran

3.1: Pd(PPh₃)4 / tetrahydrofuran; dimethylformamide

4.1: TBAF / tetrahydrofuran

5.1: Dess-Martin periodinane / CH₂Cl₂

6.1: Sn(OTf)2; 1-ethylpiperidine / CH₂Cl₂

7.1: 2,6-lutidine / CH₂Cl₂

8.1: DIBAL-H / toluene

9.1: Sn(OTf)2; 1-ethylpiperidine / CH₂Cl₂

10.1: MeONHMe*HCl; AlMe₃ / CH₂Cl₂

10.2: 4-DMAP; pyridine / CH₂Cl₂ / 72 h / 20 °C

11.1: DIBAL-H / tetrahydrofuran / -78 °C

With 1-ethyl-piperidine; 1H-imidazole; 2,6-dimethylpyridine; tin(II) trifluoromethanesulfonate; zirconocene dichloride; tetrabutyl ammonium fluoride; trimethylaluminum; N,O-dimethylhydroxylamine*hydrochloride; diisobutylaluminium hydride; Dess-Martin periodane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 3.1: Negishi coupling;
DOI:10.1055/s-2006-926263

Reference yield:

: 61362-77-4
5-[tert-butyldimethylsilyloxy]pent-1-yne

: 883907-97-9
2,2-Dimethyl-propionic acid (E)-(1S,3R)-3-(tert-butyl-dimethyl-silanyloxy)-6-methyl-1-(2-oxo-ethyl)-8-phenyl-oct-6-enyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: aq. Cp₂ZrCl₂ / CH₂Cl₂ / 4 h / -23 °C

1.2: I₂ / tetrahydrofuran

2.1: Pd(PPh₃)4 / tetrahydrofuran; dimethylformamide

3.1: TBAF / tetrahydrofuran

4.1: Dess-Martin periodinane / CH₂Cl₂

5.1: Sn(OTf)2; 1-ethylpiperidine / CH₂Cl₂

6.1: 2,6-lutidine / CH₂Cl₂

7.1: DIBAL-H / toluene

8.1: Sn(OTf)2; 1-ethylpiperidine / CH₂Cl₂

9.1: MeONHMe*HCl; AlMe₃ / CH₂Cl₂

9.2: 4-DMAP; pyridine / CH₂Cl₂ / 72 h / 20 °C

10.1: DIBAL-H / tetrahydrofuran / -78 °C

With 1-ethyl-piperidine; 2,6-dimethylpyridine; tin(II) trifluoromethanesulfonate; zirconocene dichloride; tetrabutyl ammonium fluoride; trimethylaluminum; N,O-dimethylhydroxylamine*hydrochloride; diisobutylaluminium hydride; Dess-Martin periodane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 2.1: Negishi coupling;
DOI:10.1055/s-2006-926263