(R)-2-[2-Benzenesulfinyl-1-methoxy-eth-(E)-ylidene]-5-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-furan-2-yl-pentan-1-ol

Base Information

Chemical Name:(R)-2-[2-Benzenesulfinyl-1-methoxy-eth-(E)-ylidene]-5-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-furan-2-yl-pentan-1-ol
CAS No.:256343-65-4
Molecular Formula:C₂₃H₃₀O₆S
Molecular Weight:434.554
Hs Code.:

Synonyms:(R)-2-[2-Benzenesulfinyl-1-methoxy-eth-(E)-ylidene]-5-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-furan-2-yl-pentan-1-ol

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Chemical Property of (R)-2-[2-Benzenesulfinyl-1-methoxy-eth-(E)-ylidene]-5-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-furan-2-yl-pentan-1-ol

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Technology Process of (R)-2-[2-Benzenesulfinyl-1-methoxy-eth-(E)-ylidene]-5-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-furan-2-yl-pentan-1-ol

There total 8 articles about (R)-2-[2-Benzenesulfinyl-1-methoxy-eth-(E)-ylidene]-5-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-furan-2-yl-pentan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 256343-64-3
(3'R,4''S)-methyl 2-[3'-(2-dimethyl-1,3-dioxolan-4-yl)-3'-(2'-furyl)]propyl-3-methoxy-4-methylsulfinyl-2-butenoate

: 256343-65-4
(R)-2-[2-Benzenesulfinyl-1-methoxy-eth-(E)-ylidene]-5-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-furan-2-yl-pentan-1-ol

Guidance literature:: With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃; for 2h;
DOI:10.1016/S0040-4020(99)00882-0

Reference yield:

: 64520-58-7,917877-01-1
ethyl (E)-3-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)acrylate

: 256343-65-4
(R)-2-[2-Benzenesulfinyl-1-methoxy-eth-(E)-ylidene]-5-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-furan-2-yl-pentan-1-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: diethyl ether / 2 h / -78 °C

2.1: 3.78 g / LiAlH₄ / tetrahydrofuran / 6 h / Heating

3.1: TsCl; pyridine

3.2: 85 percent / NaI

4.1: NaH / tetrahydrofuran / 1 h / 0 °C

4.2: 90 percent / tetrahydrofuran / 27 h / Heating

5.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

5.2: n-BuLi / tetrahydrofuran; hexane / 1.5 h / -15 °C

5.3: 75 percent / tetrahydrofuran; hexane / -15 - 20 °C

6.1: m-CPBA / CHCl₃ / 1.5 h / 0 °C

7.1: 240 mg / diethyl ether / 2 h / 0 °C

8.1: 17 mg / Dibal / hexane; CH₂Cl₂ / 2 h / -78 °C

With pyridine; lithium aluminium tetrahydride; sodium hydride; diisobutylaluminium hydride; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; chloroform; 1.1: Addition / 2.1: Reduction / 3.1: Tosylation / 3.2: Iodination / 4.1: Metallation / 4.2: Alkylation / 5.1: Metallation / 5.2: Metallation / 5.3: Substitution / 6.1: Oxidation / 7.1: Methylation / 8.1: Reduction;
DOI:10.1016/S0040-4020(99)00882-0

Reference yield:

: 256343-60-9
(3R,4'S)-3-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-3-(2-furyl)-propanol

: 256343-65-4
(R)-2-[2-Benzenesulfinyl-1-methoxy-eth-(E)-ylidene]-5-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-furan-2-yl-pentan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: TsCl; pyridine

1.2: 85 percent / NaI

2.1: NaH / tetrahydrofuran / 1 h / 0 °C

2.2: 90 percent / tetrahydrofuran / 27 h / Heating

3.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

3.2: n-BuLi / tetrahydrofuran; hexane / 1.5 h / -15 °C

3.3: 75 percent / tetrahydrofuran; hexane / -15 - 20 °C

4.1: m-CPBA / CHCl₃ / 1.5 h / 0 °C

5.1: 240 mg / diethyl ether / 2 h / 0 °C

6.1: 17 mg / Dibal / hexane; CH₂Cl₂ / 2 h / -78 °C

With pyridine; sodium hydride; diisobutylaluminium hydride; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; chloroform; 1.1: Tosylation / 1.2: Iodination / 2.1: Metallation / 2.2: Alkylation / 3.1: Metallation / 3.2: Metallation / 3.3: Substitution / 4.1: Oxidation / 5.1: Methylation / 6.1: Reduction;
DOI:10.1016/S0040-4020(99)00882-0