tert-butyl (S)-1-((S)-1-cyclohexyl-2-(methyl((S)-piperidin-3-yl)amino)-2-oxoethylamino)-1-oxopropan-2-yl(methyl)carbamate

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Chemical Name:tert-butyl (S)-1-((S)-1-cyclohexyl-2-(methyl((S)-piperidin-3-yl)amino)-2-oxoethylamino)-1-oxopropan-2-yl(methyl)carbamate
CAS No.:1361323-18-3
Molecular Formula:C₂₃H₄₂N₄O₄
Molecular Weight:438.611
Hs Code.:

Synonyms:tert-butyl (S)-1-((S)-1-cyclohexyl-2-(methyl((S)-piperidin-3-yl)amino)-2-oxoethylamino)-1-oxopropan-2-yl(methyl)carbamate

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Chemical Property of tert-butyl (S)-1-((S)-1-cyclohexyl-2-(methyl((S)-piperidin-3-yl)amino)-2-oxoethylamino)-1-oxopropan-2-yl(methyl)carbamate

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Technology Process of tert-butyl (S)-1-((S)-1-cyclohexyl-2-(methyl((S)-piperidin-3-yl)amino)-2-oxoethylamino)-1-oxopropan-2-yl(methyl)carbamate

There total 7 articles about tert-butyl (S)-1-((S)-1-cyclohexyl-2-(methyl((S)-piperidin-3-yl)amino)-2-oxoethylamino)-1-oxopropan-2-yl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1361323-17-2
(S)-benzyl 3-((S)-2-((S)-2-(tert-butoxycarbonyl(methyl)amino)propanamido)-2-cyclohexyl-N-methylacetamido)piperidine-1-carboxylate

: 1361323-18-3
tert-butyl (S)-1-((S)-1-cyclohexyl-2-(methyl((S)-piperidin-3-yl)amino)-2-oxoethylamino)-1-oxopropan-2-yl(methyl)carbamate

Guidance literature:: With palladium 10% on activated carbon; ammonium formate; In methanol; at 20 ℃; for 1.5h;
DOI:10.1016/j.bmcl.2011.12.109

Reference yield:

: 876379-22-5
benzyl (3S)-3-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-1-carboxylate

: 1361323-18-3
tert-butyl (S)-1-((S)-1-cyclohexyl-2-(methyl((S)-piperidin-3-yl)amino)-2-oxoethylamino)-1-oxopropan-2-yl(methyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 20 °C

1.2: 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h / 0 °C

3.2: 0 - 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

5.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0 °C

5.2: 0 - 20 °C

6.1: palladium 10% on activated carbon; ammonium formate / methanol / 1.5 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; palladium 10% on activated carbon; ammonium formate; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2011.12.109

Reference yield:

: 1124199-24-1,1284966-16-0
benzyl (3S)-3-[tert-butoxycarbonyl(methyl)amino]piperidine-1-carboxylate

: 1361323-18-3
tert-butyl (S)-1-((S)-1-cyclohexyl-2-(methyl((S)-piperidin-3-yl)amino)-2-oxoethylamino)-1-oxopropan-2-yl(methyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h / 0 °C

2.2: 0 - 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

4.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0 °C

4.2: 0 - 20 °C

5.1: palladium 10% on activated carbon; ammonium formate / methanol / 1.5 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; palladium 10% on activated carbon; ammonium formate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.12.109