7-Chloro-3-(3-methylphenyl)pyrazolo[1,5-a]pyrimidine

Base Information

Chemical Name:7-Chloro-3-(3-methylphenyl)pyrazolo[1,5-a]pyrimidine
CAS No.:77493-94-8
Molecular Formula:C₁₃H₁₀ClN₃
Molecular Weight:243.695
Hs Code.:
DSSTox Substance ID:DTXSID801218597

Synonyms:7-Chloro-3-(3-methylphenyl)pyrazolo[1,5-a]pyrimidine;DTXSID801218597;77493-94-8

Suppliers and Price of 7-Chloro-3-(3-methylphenyl)pyrazolo[1,5-a]pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-Chloro-3-(3-methylphenyl)pyrazolo[1,5-a]pyrimidine

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:243.0563250
Heavy Atom Count:17
Complexity:273

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=CC=C1)C2=C3N=CC=C(N3N=C2)Cl

Technology Process of 7-Chloro-3-(3-methylphenyl)pyrazolo[1,5-a]pyrimidine

There total 3 articles about 7-Chloro-3-(3-methylphenyl)pyrazolo[1,5-a]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 77493-83-5
3-(m-tolyl)pyrazolo<1,5-a>pyrimidin-6-one

: 77493-94-8
7-chloro-3-(m-tolyl)pyrazolo<1,5-a>pyrimidine

Guidance literature:: With N,N-dimethyl-aniline; trichlorophosphate; for 2h; Heating;
DOI:10.1002/jhet.5570220303

Reference yield:

3-amino-4-(m-tolyl)pyrazole: 40545-62-8
3-amino-4-(m-tolyl)pyrazole

: 77493-94-8
7-chloro-3-(m-tolyl)pyrazolo<1,5-a>pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / acetic acid / 3 h / Heating

2: 0.5 g / 1.) 40percent H₂SO₄; 2.) 2 N NaOH / 2 h / Heating

3: 82 percent / N,N-dimethylaniline, POCl₃ / 2 h / Heating

With sodium hydroxide; sulfuric acid; N,N-dimethyl-aniline; trichlorophosphate; In acetic acid;
DOI:10.1002/jhet.5570220303

Reference yield:

: 99898-54-1
6-carbethoxy-3-(m-tolyl)pyrazolo<1,5-a>pyrimidin-7-one

: 77493-94-8
7-chloro-3-(m-tolyl)pyrazolo<1,5-a>pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 0.5 g / 1.) 40percent H₂SO₄; 2.) 2 N NaOH / 2 h / Heating

2: 82 percent / N,N-dimethylaniline, POCl₃ / 2 h / Heating

With sodium hydroxide; sulfuric acid; N,N-dimethyl-aniline; trichlorophosphate;
DOI:10.1002/jhet.5570220303