N-[4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]phenylsulfonyl]phosphoramidatic acid

Base Information

Chemical Name:N-[4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]phenylsulfonyl]phosphoramidatic acid
CAS No.:721445-64-3
Molecular Formula:C₁₆H₁₄ClFN₃O₆PS
Molecular Weight:461.795
Hs Code.:

Synonyms:N-[4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]phenylsulfonyl]phosphoramidatic acid

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Chemical Property of N-[4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]phenylsulfonyl]phosphoramidatic acid

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Technology Process of N-[4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]phenylsulfonyl]phosphoramidatic acid

There total 2 articles about N-[4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]phenylsulfonyl]phosphoramidatic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 721445-59-6
diethyl N-[4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]phenylsulfonyl]phosphoramidate

: 721445-64-3
N-[4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]phenylsulfonyl]phosphoramidatic acid

Guidance literature:: diethyl N-[4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]phenylsulfonyl]phosphoramidate; With trimethylsilyl iodide; In dichloromethane; at 0 ℃; for 1h;

With water; In acetone; at 20 ℃;
DOI:10.1021/jm040844j

Reference yield:

: 265114-23-6
cimicoxib

: 721445-64-3
N-[4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]phenylsulfonyl]phosphoramidatic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 74 percent / aq. NaOH / tetrahydrofuran / 1 h / 20 °C

2.1: iodotrimethylsilane / CH₂Cl₂ / 1 h / 0 °C

2.2: 80 percent / H₂O / acetone / 20 °C

With sodium hydroxide; trimethylsilyl iodide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm040844j