(6R)-3-methylene-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid 4-nitro-benzyl ester

Base Information

• Chemical Name: (6R)-3-methylene-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid 4-nitro-benzyl ester
• CAS No.: 60761-30-0
• Molecular Formula: C₂₃H₂₁N₃O₇S
• Molecular Weight: 483.502

Synonyms:(6R)-3-methylene-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid 4-nitro-benzyl ester

Chemical Property of (6R)-3-methylene-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid 4-nitro-benzyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (6R)-3-methylene-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid 4-nitro-benzyl ester

There total 5 articles about (6R)-3-methylene-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-nitrobenzyl-2-(3-phenoxymethyl-2-thia-6-oxo-4,7-diazabicyclo[3,2,0]hept-3-ene-7-yl)-3-iodomethyl-3-butenoate → p-Nitrobenzyl 7-(phenoxyacetamido)-3-methylenecepham-4-carboxylate (40704-42-5,60761-30-0,87303-97-7)

Guidance literature:

With perchloric acid; In dichloromethane; acetone;

Reference yield:

(6R)-3-methylene-5ξ,8-dioxo-7t-(2-phenoxy-acetylamino)-(6rH)-5λ4-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid 4-nitro-benzyl ester (61375-82-4) → (6R)-3-methylene-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid 4-nitro-benzyl ester (60761-30-0)

Guidance literature:

With phosphorus trichloride; In N,N-dimethyl-formamide;

DOI:10.1021/ja00450a081

Reference yield:

p-Nitrobenzyl 7-(phenoxyacetamido)-3-methylenecepham-4-carboxylate 1β-oxide (60771-27-9,61375-82-4,63427-57-6,69308-55-0,87303-96-6,119944-11-5) → p-Nitrobenzyl 7-(phenoxyacetamido)-3-methylenecepham-4-carboxylate (40704-42-5,60761-30-0,87303-97-7)

Guidance literature:

With Acetyl bromide; In dichloromethane; at 0 ℃; for 0.333333h;

DOI:10.1021/jo00001a086

upstream raw materials:

p-Nitrobenzyl 7-(phenoxyacetamido)-3-methylenecepham-4-carboxylate 1β-oxide

(6R)-3-methylene-5ξ,8-dioxo-7t-(2-phenoxy-acetylamino)-(6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid 4-nitro-benzyl ester

(4R,6R,7R)-4-nitrobenzyl 3-methylene-7-phenoxyacetamidocepham-4-carboxylate-1-oxide

Downstream raw materials:

(6R)-3-bromomethyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

(6R)-3-iodomethyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

C₁₈H₂₀N₄O₅S

C₂₄H₂₃N₅O₇S

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