3-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-N-methyl-4-[1,2,4]triazol-1-ylbenzamide

Base Information

Chemical Name:3-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-N-methyl-4-[1,2,4]triazol-1-ylbenzamide
CAS No.:1310531-24-8
Molecular Formula:C₂₅H₂₅N₉O
Molecular Weight:467.533
Hs Code.:

Synonyms:3-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-N-methyl-4-[1,2,4]triazol-1-ylbenzamide

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Chemical Property of 3-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-N-methyl-4-[1,2,4]triazol-1-ylbenzamide

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Technology Process of 3-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-N-methyl-4-[1,2,4]triazol-1-ylbenzamide

There total 7 articles about 3-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-N-methyl-4-[1,2,4]triazol-1-ylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1310530-05-2
3-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-4-1,2,4-triazol-1-ylbenzonitrile

: 75-24-1
trimethylaluminum

: 1310531-24-8
3-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-N-methyl-4-[1,2,4]triazol-1-ylbenzamide

Guidance literature:: trimethylaluminum; With methylamine hydrochloride; In toluene; at 20 ℃; for 0.25h;

3-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-4-1,2,4-triazol-1-ylbenzonitrile; In toluene; at 90 ℃; for 12h;

Reference yield:

: 364-73-8
4-Bromo-1-fluoro-2-nitrobenzene

: 1310531-24-8
3-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-N-methyl-4-[1,2,4]triazol-1-ylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 16 h / 60 °C

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 20 - 100 °C

3.1: zinc; ammonium formate / ethanol / 2 h / 50 °C

4.1: Oxone / N,N-dimethyl-formamide; water / 3 h / 20 °C

5.1: methylamine hydrochloride / toluene / 0.25 h / 20 °C

5.2: 12 h / 90 °C

With Oxone; methylamine hydrochloride; ammonium formate; potassium carbonate; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1135351-95-9
4-bromo-N-(tert-butyl)-2-nitroaniline

: 1310531-24-8
3-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-N-methyl-4-[1,2,4]triazol-1-ylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 20 - 100 °C

2.1: zinc; ammonium formate / ethanol / 2 h / 50 °C

3.1: Oxone / N,N-dimethyl-formamide; water / 3 h / 20 °C

4.1: methylamine hydrochloride / toluene / 0.25 h / 20 °C

4.2: 12 h / 90 °C

With Oxone; methylamine hydrochloride; ammonium formate; potassium carbonate; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; N,N-dimethyl-formamide; toluene;