eicosanoyl 3α-acetoxy-7α,12α-di[(phenylaminocarbonyl)amino]-5β-cholan-24-oate

Base Information

• Chemical Name: eicosanoyl 3α-acetoxy-7α,12α-di[(phenylaminocarbonyl)amino]-5β-cholan-24-oate
• CAS No.: 437613-62-2
• Molecular Formula: C₆₀H₉₄N₄O₆
• Molecular Weight: 967.43
• Mol file: 437613-62-2.mol

Synonyms:eicosanoyl 3α-acetoxy-7α,12α-di[(phenylaminocarbonyl)amino]-5β-cholan-24-oate

Chemical Property of eicosanoyl 3α-acetoxy-7α,12α-di[(phenylaminocarbonyl)amino]-5β-cholan-24-oate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of eicosanoyl 3α-acetoxy-7α,12α-di[(phenylaminocarbonyl)amino]-5β-cholan-24-oate

There total 6 articles about eicosanoyl 3α-acetoxy-7α,12α-di[(phenylaminocarbonyl)amino]-5β-cholan-24-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

phenyl isocyanate (103-71-9) + eicosanoyl 3α-acetoxy-7α,12α-diamino-5β-cholan-24-oate (437613-64-4) → eicosanoyl 3α-acetoxy-7α,12α-di[(phenylaminocarbonyl)amino]-5β-cholan-24-oate (437613-62-2)

Guidance literature:

In chloroform; at 20 ℃; for 16h;

DOI:10.1021/ja026022y

Reference yield:

eicosanoyl 3α-acetoxy-7α,12α-di[N-(t-butyloxycarbonyl)amino]-5β-cholan-24-oate → eicosanoyl 3α-acetoxy-7α,12α-di[(phenylaminocarbonyl)amino]-5β-cholan-24-oate (437613-62-2)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / CH₂Cl₂ / 17 h / 20 °C

2: 84 percent / CHCl₃ / 16 h / 20 °C

With trifluoroacetic acid; In dichloromethane; chloroform;

DOI:10.1021/ja026022y

Reference yield:

3α-hydroxy-7α,12α-di[N-(t-butyloxycarbonyl)amino]-5β-cholan-24-oic acid → eicosanoyl 3α-acetoxy-7α,12α-di[(phenylaminocarbonyl)amino]-5β-cholan-24-oate (437613-62-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / pyridine / 23 h / 20 °C

2: 78 percent / DMAP; EDC / CH₂Cl₂ / 40 h / 20 °C

3: trifluoroacetic acid / CH₂Cl₂ / 17 h / 20 °C

4: 84 percent / CHCl₃ / 16 h / 20 °C

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In pyridine; dichloromethane; chloroform;

DOI:10.1021/ja026022y

upstream raw materials:

phenyl isocyanate

eicosanoyl 3α-acetoxy-7α,12α-diamino-5β-cholan-24-oate

n-eicosanol

methyl 3α-acetoxy-7α,12α-di[N-(t-butyloxycarbonyl)amino]-5β-cholan-24-oate