10-[(3-chloro-4-methoxybenzyl)amino]-6-ethyl-2-methyl-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile

Base Information

Chemical Name:10-[(3-chloro-4-methoxybenzyl)amino]-6-ethyl-2-methyl-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile
CAS No.:1448419-09-7
Molecular Formula:C₂₄H₂₅ClN₄O
Molecular Weight:420.942
Hs Code.:

Synonyms:10-[(3-chloro-4-methoxybenzyl)amino]-6-ethyl-2-methyl-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile

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Chemical Property of 10-[(3-chloro-4-methoxybenzyl)amino]-6-ethyl-2-methyl-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile

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Technology Process of 10-[(3-chloro-4-methoxybenzyl)amino]-6-ethyl-2-methyl-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile

There total 6 articles about 10-[(3-chloro-4-methoxybenzyl)amino]-6-ethyl-2-methyl-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1448419-16-6
10-chloro-6-ethyl-2-methyl-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile

: 41965-95-1
(3-chloro-4-methoxyphenyl)methylamine hydrogen chloride

: 1448419-09-7
10-[(3-chloro-4-methoxybenzyl)amino]-6-ethyl-2-methyl-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile

Guidance literature:: With sodium iodide; phenol; at 130 ℃; for 4h;

Reference yield:

: 34921-60-3
5-bromo-7-ethylindoline-2,3-dione

: 1448419-09-7
10-[(3-chloro-4-methoxybenzyl)amino]-6-ethyl-2-methyl-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide; dihydrogen peroxide / water / 20 °C

2: 1-methyl-pyrrolidin-2-one / 4 h / Reflux

3: trichlorophosphate / 6 h / 60 °C

4: phenol; sodium iodide / 4 h / 130 °C

With dihydrogen peroxide; sodium iodide; sodium hydroxide; trichlorophosphate; phenol; In 1-methyl-pyrrolidin-2-one; water;

Reference yield:

: 34921-61-4
2-amino-5-bromo-3-ethylbenzoic acid

: 1448419-09-7
10-[(3-chloro-4-methoxybenzyl)amino]-6-ethyl-2-methyl-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 1-methyl-pyrrolidin-2-one / 4 h / Reflux

2: trichlorophosphate / 6 h / 60 °C

3: phenol; sodium iodide / 4 h / 130 °C

With sodium iodide; trichlorophosphate; phenol; In 1-methyl-pyrrolidin-2-one;