Technology Process of (4S,4aS,8aS)-4-{[(3,5-dimethoxybenzene)sulfonyl]methyl}-3,4a,8,8-tetramethyldecahydronaphthalen-2-ol
There total 8 articles about (4S,4aS,8aS)-4-{[(3,5-dimethoxybenzene)sulfonyl]methyl}-3,4a,8,8-tetramethyldecahydronaphthalen-2-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C23H34O4S;
With
borane-THF;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 1.75h;
Inert atmosphere;
With
dihydrogen peroxide; sodium hydroxide;
In
tetrahydrofuran; water;
at 0 - 20 ℃;
for 24.55h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 1,4-diaza-bicyclo[2.2.2]octane / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
2.1: neat (no solvent) / 3 h / 260 °C / Inert atmosphere
3.1: potassium hydroxide / methanol / 2 h / Reflux
4.1: caesium carbonate / acetonitrile / 25 h / 20 °C / Inert atmosphere; Reflux
5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere
6.1: trimethylsilyl methanesulfonate / acetonitrile / 24 h / Inert atmosphere
7.1: borane-THF / tetrahydrofuran / 1.75 h / 0 - 20 °C / Inert atmosphere
7.2: 24.55 h / 0 - 20 °C
With
1,4-diaza-bicyclo[2.2.2]octane; borane-THF; trimethylsilyl methanesulfonate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium hydroxide / methanol / 2 h / Reflux
2.1: caesium carbonate / acetonitrile / 25 h / 20 °C / Inert atmosphere; Reflux
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere
4.1: trimethylsilyl methanesulfonate / acetonitrile / 24 h / Inert atmosphere
5.1: borane-THF / tetrahydrofuran / 1.75 h / 0 - 20 °C / Inert atmosphere
5.2: 24.55 h / 0 - 20 °C
With
borane-THF; trimethylsilyl methanesulfonate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
