2,4-difluoro-N-(3-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)phenyl)benzene sulphonamide

Base Information

Chemical Name:2,4-difluoro-N-(3-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)phenyl)benzene sulphonamide
CAS No.:1567836-95-6
Molecular Formula:C₂₅H₁₈F₂N₂O₃S₂
Molecular Weight:496.558
Hs Code.:

Synonyms:2,4-difluoro-N-(3-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)phenyl)benzene sulphonamide

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Chemical Property of 2,4-difluoro-N-(3-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)phenyl)benzene sulphonamide

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Technology Process of 2,4-difluoro-N-(3-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)phenyl)benzene sulphonamide

There total 2 articles about 2,4-difluoro-N-(3-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)phenyl)benzene sulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1567836-94-5
5-(5-(3-aminophenyl)thiophen-2-yl)-2-methylisoindolin-1-one

: 13918-92-8
2,4-difluorobenzene-1-sulfonyl chloride

: 1567836-95-6
2,4-difluoro-N-(3-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)phenyl)benzene sulphonamide

Guidance literature:: With pyridine; In dichloromethane; at 20 - 45 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2017.05.048

Reference yield:

: 1567836-36-5
5-(5-iodothiophen-2-yl)-2-methylisoindolin-1-one

: 30418-59-8,280563-63-5
3-Aminophenylboronic acid

: 1567836-95-6
2,4-difluoro-N-(3-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)phenyl)benzene sulphonamide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / ethanol; toluene / 2 h / Reflux

2: pyridine / dichloromethane / 20 - 45 °C / Inert atmosphere

With pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In ethanol; dichloromethane; toluene; 1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2017.05.048