tert-butyl N-[4-([6-ethylthieno[2,3-d]pyrimidin-4-yl]amino)cyclohexyl]carbarnate

Base Information

• Chemical Name: tert-butyl N-[4-([6-ethylthieno[2,3-d]pyrimidin-4-yl]amino)cyclohexyl]carbarnate
• CAS No.: 1388892-05-4
• Molecular Formula: C₁₉H₂₈N₄O₂S
• Molecular Weight: 376.523
• Mol file: 1388892-05-4.mol

Synonyms:tert-butyl N-[4-([6-ethylthieno[2,3-d]pyrimidin-4-yl]amino)cyclohexyl]carbarnate

Chemical Property of tert-butyl N-[4-([6-ethylthieno[2,3-d]pyrimidin-4-yl]amino)cyclohexyl]carbarnate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl N-[4-([6-ethylthieno[2,3-d]pyrimidin-4-yl]amino)cyclohexyl]carbarnate

There total 4 articles about tert-butyl N-[4-([6-ethylthieno[2,3-d]pyrimidin-4-yl]amino)cyclohexyl]carbarnate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + C14H20N4S (1388891-97-1) → tert-butyl N-[4-([6-ethylthieno[2,3-d]pyrimidin-4-yl]amino)cyclohexyl]carbarnate (1388892-05-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

6-ethyl-3H-thieno[2,3-d]pyrimidin-4-one (18593-51-6) → tert-butyl N-[4-([6-ethylthieno[2,3-d]pyrimidin-4-yl]amino)cyclohexyl]carbarnate (1388892-05-4)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / 1,4-dioxane / 4 h / Reflux

2: triethylamine / N,N-dimethyl-formamide / 30 °C

3: triethylamine / dichloromethane / 3 h / 20 °C

With triethylamine; trichlorophosphate; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

ethyl 2-amino-5-ethylthiophene-3-carboxylate (4507-13-5) → tert-butyl N-[4-([6-ethylthieno[2,3-d]pyrimidin-4-yl]amino)cyclohexyl]carbarnate (1388892-05-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 4 h / 180 °C

2: trichlorophosphate / 1,4-dioxane / 4 h / Reflux

3: triethylamine / N,N-dimethyl-formamide / 30 °C

4: triethylamine / dichloromethane / 3 h / 20 °C

With triethylamine; trichlorophosphate; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

di-tert-butyl dicarbonate

C₁₄H₂₀N₄S

ethyl 2-amino-5-ethylthiophene-3-carboxylate

4-chloro-6-ethylthieno<2,3-d>pyrimidine

Downstream raw materials:

1-N-[6-ethylthieno[2,3-d]pyrimidin-4-yl]4-N-methylcyclohexane-1,4-diamine