Technology Process of 2-hydroxyl-3,3,4-triphenyl butyronitrile
There total 6 articles about 2-hydroxyl-3,3,4-triphenyl butyronitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2,2,3-triphenyl-propionaldehyde;
With
sodium hydrogensulfite;
In
tetrahydrofuran; water;
for 0.5h;
Cooling with ice;
sodium cyanide;
In
tetrahydrofuran; water;
at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2011.05.034
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C
2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C
2.2: 12 h / 0 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 °C
4.1: pyridinium chlorochromate / dichloromethane / 20 °C
5.1: sodium hydrogensulfite / tetrahydrofuran; water / 0.5 h / Cooling with ice
5.2: 0 - 20 °C
With
lithium aluminium tetrahydride; sodium hydride; potassium carbonate; sodium hydrogensulfite; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.05.034
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: pyridinium chlorochromate / dichloromethane / 20 °C
2.1: sodium hydrogensulfite / tetrahydrofuran; water / 0.5 h / Cooling with ice
2.2: 0 - 20 °C
With
sodium hydrogensulfite; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.bmcl.2011.05.034
