N-(2-(6,7-dimethoxyquinazolin-4-yl)hydrazinecarbonothioyl)-4-(trifluoromethyl)benzamide

Base Information

Chemical Name:N-(2-(6,7-dimethoxyquinazolin-4-yl)hydrazinecarbonothioyl)-4-(trifluoromethyl)benzamide
CAS No.:1394045-64-7
Molecular Formula:C₁₉H₁₆F₃N₅O₃S
Molecular Weight:451.429
Hs Code.:

Synonyms:N-(2-(6,7-dimethoxyquinazolin-4-yl)hydrazinecarbonothioyl)-4-(trifluoromethyl)benzamide

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Chemical Property of N-(2-(6,7-dimethoxyquinazolin-4-yl)hydrazinecarbonothioyl)-4-(trifluoromethyl)benzamide

Chemical Property:

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Technology Process of N-(2-(6,7-dimethoxyquinazolin-4-yl)hydrazinecarbonothioyl)-4-(trifluoromethyl)benzamide

There total 4 articles about N-(2-(6,7-dimethoxyquinazolin-4-yl)hydrazinecarbonothioyl)-4-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 91163-69-8
4-hydrazinyl-6,7-dimethoxyquinazoline

: 880483-26-1
4-Trifluoromethyl-benzoyl isothiocyanate

: 1394045-64-7
N-(2-(6,7-dimethoxyquinazolin-4-yl)hydrazinecarbonothioyl)-4-(trifluoromethyl)benzamide

Guidance literature:: In 1,4-dioxane; at 20 ℃;
DOI:10.1016/j.ejmech.2012.06.003

Reference yield:

: 13790-39-1
6,7-dimethoxy-4-chloroquinazoline

: 1394045-64-7
N-(2-(6,7-dimethoxyquinazolin-4-yl)hydrazinecarbonothioyl)-4-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / tetrahydrofuran / 16 h / 20 °C

2: 1,4-dioxane / 20 °C

With hydrazine hydrate; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/j.ejmech.2012.06.003

Reference yield:

: 13794-72-4
3H-6,7-dimethoxyquinazolin-4-one

: 1394045-64-7
N-(2-(6,7-dimethoxyquinazolin-4-yl)hydrazinecarbonothioyl)-4-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 78 °C

2: hydrazine hydrate / tetrahydrofuran / 16 h / 20 °C

3: 1,4-dioxane / 20 °C

With thionyl chloride; hydrazine hydrate; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/j.ejmech.2012.06.003