2-[(4-phenyl)-1,2,3-triazol-1H-yl]-2′,3′-5′-tri-O-(tert-butyldimethylsilyl)inosine

Base Information

Chemical Name:2-[(4-phenyl)-1,2,3-triazol-1H-yl]-2′,3′-5′-tri-O-(tert-butyldimethylsilyl)inosine
CAS No.:1398237-71-2
Molecular Formula:C₃₆H₅₉N₇O₅Si₃
Molecular Weight:754.165
Hs Code.:

Synonyms:2-[(4-phenyl)-1,2,3-triazol-1H-yl]-2′,3′-5′-tri-O-(tert-butyldimethylsilyl)inosine

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Chemical Property of 2-[(4-phenyl)-1,2,3-triazol-1H-yl]-2′,3′-5′-tri-O-(tert-butyldimethylsilyl)inosine

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Technology Process of 2-[(4-phenyl)-1,2,3-triazol-1H-yl]-2′,3′-5′-tri-O-(tert-butyldimethylsilyl)inosine

There total 4 articles about 2-[(4-phenyl)-1,2,3-triazol-1H-yl]-2′,3′-5′-tri-O-(tert-butyldimethylsilyl)inosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1384519-66-7
O⁶-allyl-2-(4-phenyl-1,2,3-triazol-1H-yl)-2',3',5'-tri-O-(tert-butyldimethylsilyl)inosine

: 1398237-71-2
2-(4-phenyl-1,2,3-triazol-1H-yl)-2',3',5'-tri-O-(tert-butyldimethylsilyl)inosine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium benzenesulfonate; In tetrahydrofuran; methanol; at 20 ℃; for 2h;
DOI:10.1021/jo300628y

Reference yield:

: 72409-24-6
2',3',5'-tri-O-(tert-butyldimethylsilyl)guanosine

: 1398237-71-2
2-(4-phenyl-1,2,3-triazol-1H-yl)-2',3',5'-tri-O-(tert-butyldimethylsilyl)inosine

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

2: caesium carbonate / 2 h / 20 °C / Inert atmosphere

3: tert.-butylnitrite; trimethylsilylazide / dichloromethane / 25 h / -20 - 20 °C

4: copper(l) chloride / water; tert-butyl alcohol / 20 °C / Inert atmosphere

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium benzenesulfonate / tetrahydrofuran; methanol / 2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; trimethylsilylazide; sodium benzenesulfonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; copper(l) chloride; In tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jo300628y

Reference yield:

: 1182847-58-0
O⁶-allyl-2',3',5'-tri-O-(tert-butyldimethylsilyl)guanosine

: 1398237-71-2
2-(4-phenyl-1,2,3-triazol-1H-yl)-2',3',5'-tri-O-(tert-butyldimethylsilyl)inosine

Guidance literature:: Multi-step reaction with 3 steps

1: tert.-butylnitrite; trimethylsilylazide / dichloromethane / 25 h / -20 - 20 °C

2: copper(l) chloride / water; tert-butyl alcohol / 20 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium benzenesulfonate / tetrahydrofuran; methanol / 2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; trimethylsilylazide; sodium benzenesulfonate; copper(l) chloride; In tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jo300628y