2-chloro-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-nicotinonitrile

Base Information

Chemical Name:2-chloro-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-nicotinonitrile
CAS No.:634588-38-8
Molecular Formula:C₁₉H₁₄ClN₅O
Molecular Weight:363.806
Hs Code.:

2-chloro-6-[(4-cyano-phenyl)-(3-methyl-3<i>H</i>-imidazol-4-yl)-methoxymethyl]-nicotinonitrile

Synonyms:2-chloro-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-nicotinonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-chloro-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-nicotinonitrile

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Technology Process of 2-chloro-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-nicotinonitrile

There total 2 articles about 2-chloro-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 368426-79-3
6-(bromomethyl)-2-chloropyridine-3-carbonitrile

: 371765-91-2
4-(hydroxy(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile

: 634588-38-8
2-chloro-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-nicotinonitrile

Guidance literature:: With silver(l) oxide; In dichloromethane; at 20 ℃;
DOI:10.1016/S0960-894X(03)00195-1

Reference yield:

: 105-07-7
4-cyanobenzaldehyde

: 634588-38-8
2-chloro-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-nicotinonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: t-BuLi / tetrahydrofuran / -78 °C

1.2: 79 percent / tetrahydrofuran

2.1: Ag₂O / CH₂Cl₂ / 20 °C

With tert.-butyl lithium; silver(l) oxide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0960-894X(03)00195-1

Reference yield:

: 67492-50-6
(3,5-dichlorophenyl)boronic acid

: 634588-38-8
2-chloro-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-nicotinonitrile

: 6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-2-(3,5-dichloro-phenyl)-nicotinonitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; toluene; Heating;
DOI:10.1016/S0960-894X(03)00195-1