4-({2-[4-(3-chloropropoxy)phenyl]-4-methyl-1,3-thiazol-5-yl}carbonyl)morpholine

Base Information

Chemical Name:4-({2-[4-(3-chloropropoxy)phenyl]-4-methyl-1,3-thiazol-5-yl}carbonyl)morpholine
CAS No.:911135-46-1
Molecular Formula:C₁₈H₂₁ClN₂O₃S
Molecular Weight:380.895
Hs Code.:

Synonyms:4-({2-[4-(3-chloropropoxy)phenyl]-4-methyl-1,3-thiazol-5-yl}carbonyl)morpholine

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Chemical Property of 4-({2-[4-(3-chloropropoxy)phenyl]-4-methyl-1,3-thiazol-5-yl}carbonyl)morpholine

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Technology Process of 4-({2-[4-(3-chloropropoxy)phenyl]-4-methyl-1,3-thiazol-5-yl}carbonyl)morpholine

There total 6 articles about 4-({2-[4-(3-chloropropoxy)phenyl]-4-methyl-1,3-thiazol-5-yl}carbonyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 110-91-8,99108-56-2
morpholine

: 911135-45-0
2-[4-(3-chloropropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid

: 911135-46-1
4-({2-[4-(3-chloropropoxy)phenyl]-4-methyl-1,3-thiazol-5-yl}carbonyl)morpholine

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 110-91-8,99108-56-2
morpholine

: C₁₄H₁₃Cl₂NO₂S

: 911135-46-1
4-({2-[4-(3-chloropropoxy)phenyl]-4-methyl-1,3-thiazol-5-yl}carbonyl)morpholine

Guidance literature:: With triethylamine; In dichloromethane; at 5 - 20 ℃;
DOI:10.1002/cmdc.200900446

Reference yield:

: 619-57-8
p-hydroxybenzamide

: 911135-46-1
4-({2-[4-(3-chloropropoxy)phenyl]-4-methyl-1,3-thiazol-5-yl}carbonyl)morpholine

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / butanone / 48 h / Heating / reflux

2.1: Lawessons reagent / chloroform; toluene / 85 °C

3.1: methanol / 5 h / 70 - 100 °C

4.1: methanol; sodium hydroxide; water / 70 °C

4.2: pH 2

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

With Lawessons reagent; methanol; sodium hydroxide; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane; chloroform; toluene; butanone;