1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]-carbonyl}amino)cyclohexanecarboxylic acid

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Chemical Name:1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]-carbonyl}amino)cyclohexanecarboxylic acid
CAS No.:1612188-96-1
Molecular Formula:C₂₄H₂₄FN₃O₄
Molecular Weight:437.471
Hs Code.:

Synonyms:1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]-carbonyl}amino)cyclohexanecarboxylic acid

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Chemical Property of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]-carbonyl}amino)cyclohexanecarboxylic acid

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Technology Process of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]-carbonyl}amino)cyclohexanecarboxylic acid

There total 6 articles about 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]-carbonyl}amino)cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1612148-95-4
methyl 1-(1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazole-3-carboxamido)cyclohexanecarboxylate

: 1612188-96-1
1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]-carbonyl}amino)cyclohexanecarboxylic acid

Guidance literature:: methyl 1-(1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazole-3-carboxamido)cyclohexanecarboxylate; With lithium hydroxide; In 1,4-dioxane; at 20 ℃; for 16h; Inert atmosphere;

With hydrogenchloride; In water; Inert atmosphere;
DOI:10.1021/jm5003843

Reference yield: 85.0%

: 1612188-96-1
1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]-carbonyl}amino)cyclohexanecarboxylic acid

Guidance literature:: With water; lithium hydroxide; In 1,4-dioxane; at 20 ℃; Inert atmosphere;

Reference yield:

: 1612148-79-4
methyl 1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazole-3-carboxylate

: 1612188-96-1
1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]-carbonyl}amino)cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 16 h / 20 °C / Inert atmosphere

3.1: lithium hydroxide / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

3.2: Inert atmosphere

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; lithium hydroxide; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm5003843