7-methoxymethyloxy-3-[4-(methoxymethyloxy)phenyl]-3-methylthiochroman-4-one

Base Information

Chemical Name:7-methoxymethyloxy-3-[4-(methoxymethyloxy)phenyl]-3-methylthiochroman-4-one
CAS No.:209325-33-7
Molecular Formula:C₂₀H₂₂O₅S
Molecular Weight:374.458
Hs Code.:

Synonyms:7-methoxymethyloxy-3-[4-(methoxymethyloxy)phenyl]-3-methylthiochroman-4-one

Suppliers and Price of 7-methoxymethyloxy-3-[4-(methoxymethyloxy)phenyl]-3-methylthiochroman-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 7-methoxymethyloxy-3-[4-(methoxymethyloxy)phenyl]-3-methylthiochroman-4-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 7-methoxymethyloxy-3-[4-(methoxymethyloxy)phenyl]-3-methylthiochroman-4-one

There total 1 articles about 7-methoxymethyloxy-3-[4-(methoxymethyloxy)phenyl]-3-methylthiochroman-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 7-hydroxy-3-(4-hydroxyphenyl)-3-methylthiochroman-4-one

: 107-30-2
chloromethyl methyl ether

: 209325-33-7
7-methoxymethyloxy-3-[4-(methoxymethyloxy)phenyl]-3-methylthiochroman-4-one

Guidance literature:: With potassium carbonate; In acetone; for 8h;

Reference yield: 79.0%

: 209325-33-7
7-methoxymethyloxy-3-[4-(methoxymethyloxy)phenyl]-3-methylthiochroman-4-one

: 252947-21-0
3-[4-(2-t-butyldimethylsilyloxyethoxy)phenoxy]-1-propyne

: 252947-22-1
4-{3-[4-(2-t-butyldimethylsilyloxyethoxy)phenoxy]-1-propynyl}-4-hydroxy-7-methoxymethoxy-3-[4-(methoxymethoxy)phenyl]-3-methylthiochroman

Guidance literature:: 3-[4-(2-t-butyldimethylsilyloxyethoxy)phenoxy]-1-propyne; With n-butyllithium; In tetrahydrofuran; at -78 - -10 ℃; for 1h;

7-methoxymethyloxy-3-[4-(methoxymethyloxy)phenyl]-3-methylthiochroman-4-one; In tetrahydrofuran; for 3h;

Reference yield:

: 209325-33-7
7-methoxymethyloxy-3-[4-(methoxymethyloxy)phenyl]-3-methylthiochroman-4-one

: C₃₅H₄₉F₅N₂O₇S₂

Guidance literature:: Multi-step reaction with 8 steps

1.1: nBuLi / tetrahydrofuran / -20 - 0 °C

1.2: ZnI₂; NaBH₃CN / 1,2-dichloro-ethane / 0 - 20 °C

2.1: H₂; aq. NaHCO₃ / tetrahydrofuran / 20 °C

3.1: TBAF / tetrahydrofuran / 20 °C

4.1: Et₃N / CH₂Cl₂ / 20 °C

5.1: NaN₃ / dimethylformamide / 20 °C

6.1: H₂ / Pd/C / methanol / 20 °C

7.1: pyridine / tetrahydrofuran / 20 °C

8.1: K₂CO₃ / dimethylformamide / 70 °C

With pyridine; n-butyllithium; sodium azide; tetrabutyl ammonium fluoride; hydrogen; sodium hydrogencarbonate; potassium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.04.090