(S)-1-[4-(trifluoromethyl)phenyl]propylamine

Base Information

• Chemical Name: (S)-1-[4-(trifluoromethyl)phenyl]propylamine
• CAS No.: 1003887-67-9
• Molecular Formula: C₁₀H₁₂F₃N
• Molecular Weight: 203.207
• Mol file: 1003887-67-9.mol

Synonyms:(S)-1-[4-(trifluoromethyl)phenyl]propylamine

Chemical Property of (S)-1-[4-(trifluoromethyl)phenyl]propylamine

Chemical Property:

• Boiling Point: 224.1±35.0 °C(Predicted)
• PKA: 8.86±0.10(Predicted)
• Density: 1.150±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

(S)-1-(4-(Trifluoromethyl)phenyl)propan-1-amine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-[4-(trifluoromethyl)phenyl]propylamine

There total 3 articles about (S)-1-[4-(trifluoromethyl)phenyl]propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

(S)-2-(S)-1-[4-(trifluoromethyl)phenyl]propylamino-2-phenylethanol (1003887-66-8) → (S)-1-[4-(trifluoromethyl)phenyl]propylamine (1003887-67-9,885276-54-0)

Guidance literature:

With periodic acid; methylamine; In methanol; water; at 0 - 20 ℃;

Reference yield:

4-trifluoromethyl propiophenone (711-33-1) → (S)-1-[4-(trifluoromethyl)phenyl]propylamine (1003887-67-9,885276-54-0)

Guidance literature:

With pyridoxal 5'-phosphate; transaminase ATA-237; isopropylamine; In aq. phosphate buffer; dimethyl sulfoxide; at 30 ℃; for 24h; pH=7.5; stereoselective reaction; Enzymatic reaction;

DOI:10.1039/c6gc01981a

Reference yield:

(+/-)-1-<4-(trifluoromethyl)phenyl>-1-propanol (67081-98-5) → (S)-1-[4-(trifluoromethyl)phenyl]propylamine (1003887-67-9,885276-54-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; Trametes versicolor laccase / tert-butyl methyl ether / 16 h / 30 °C / pH 5 / Enzymatic reaction

2: isopropylamine; pyridoxal 5'-phosphate; transaminase ATA-237 / aq. phosphate buffer; dimethyl sulfoxide / 24 h / 30 °C / pH 7.5 / Enzymatic reaction

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; Trametes versicolor laccase; pyridoxal 5'-phosphate; transaminase ATA-237; isopropylamine; In aq. phosphate buffer; tert-butyl methyl ether; dimethyl sulfoxide;

DOI:10.1039/c6gc01981a

upstream raw materials:

(S)-2-(S)-1-[4-(trifluoromethyl)phenyl]propylamino-2-phenylethanol

4-trifluoromethyl propiophenone

(+/-)-1-<4-(trifluoromethyl)phenyl>-1-propanol

Downstream raw materials:

(S)-1-(1-isocyanatopropyl)-4-(trifluoromethyl)benzene

Refernces

• 1、 -. "PROLINE UREA CCR1 ANTAGONISTS FOR AUTOIMMUNE DISEASES & INFLAMMATION". Page/Page column 35-36. . Retrieved 2008/06/13.