(10-(4-(4-Methylpiperazin-1-yl)butyl)-10H-phenothiazin-2-yl)(phenyl)methanone

Base Information

• Chemical Name: (10-(4-(4-Methylpiperazin-1-yl)butyl)-10H-phenothiazin-2-yl)(phenyl)methanone
• CAS No.: 907547-06-2
• Molecular Formula: C₂₈H₃₁N₃OS
• Molecular Weight: 457.64
• Mol file: 907547-06-2.mol

Synonyms:(10-(4-(4-Methylpiperazin-1-yl)butyl)-10H-phenothiazin-2-yl)(phenyl)methanone

Chemical Property of (10-(4-(4-Methylpiperazin-1-yl)butyl)-10H-phenothiazin-2-yl)(phenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (10-(4-(4-Methylpiperazin-1-yl)butyl)-10H-phenothiazin-2-yl)(phenyl)methanone

There total 8 articles about (10-(4-(4-Methylpiperazin-1-yl)butyl)-10H-phenothiazin-2-yl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-piperazine (109-01-3) + 4-chlorobutyl bromide (6940-78-9) → (10-(4-(4-Methylpiperazin-1-yl)butyl)-10H-phenothiazin-2-yl)(phenyl)methanone (907547-06-2)

Guidance literature:

In mineral oil;

Reference yield:

1-methyl-piperazine (109-01-3) + C23H20BrNOS → (10-(4-(4-Methylpiperazin-1-yl)butyl)-10H-phenothiazin-2-yl)(phenyl)methanone (907547-06-2)

Guidance literature:

1-methyl-piperazine; With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 1h;

C₂₃H₂₀BrNOS; In dimethyl sulfoxide; at 20 ℃; for 12h;

DOI:10.1002/ardp.200800115

Reference yield:

(3-amino-4-((2-fluorophenyl)thio)phenyl)(phenyl)methanone → (10-(4-(4-Methylpiperazin-1-yl)butyl)-10H-phenothiazin-2-yl)(phenyl)methanone (907547-06-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 8 h / 95 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 105 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

3.2: 4 h / 20 °C

4.1: potassium iodide / acetone / 18 h / 60 °C

With sodium hydride; potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; acetone; mineral oil;

upstream raw materials:

1-methyl-piperazine

4-chlorobutyl bromide

4-chloro-3-nitrobenzophenone

2-fluorothiophenol