tert-butyl (R)-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

Base Information

• Chemical Name: tert-butyl (R)-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate
• CAS No.: 473720-84-2
• Molecular Formula: C₂₃H₂₇N₃O₄
• Molecular Weight: 409.485

Synonyms:tert-butyl (R)-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

Chemical Property of tert-butyl (R)-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(R)-tert-Butyl(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate 97% ^*data from reagent suppliers

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Technology Process of tert-butyl (R)-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

There total 6 articles about tert-butyl (R)-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C23H29N3O5 (944915-91-7) → tert-butyl (R)-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate (473720-84-2)

Guidance literature:

With isobutyl chloroformate; In dichloromethane; at -25 - -15 ℃; for 6h;

DOI:10.1016/j.bmcl.2009.07.032

Reference yield:

C15H18N2O4 (944915-87-1) + 4-Ethoxyaniline (156-43-4) → tert-butyl (R)-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate (473720-84-2)

Guidance literature:

C₁₅H₁₈N₂O₄; 4-Ethoxyaniline; With 1-methyl-1H-imidazole; methanesulfonyl chloride; copper dichloride; In dichloromethane; for 16h; Molecular sieve; Inert atmosphere; Reflux;

With chloro-trimethyl-silane; triethylamine; In dichloromethane; at 0 ℃; for 24h; Molecular sieve; Inert atmosphere; Reflux;

DOI:10.1002/adsc.202001279

Reference yield:

Boc-(R)-Ala (3744-87-4,7764-95-6,15761-38-3) → tert-butyl (R)-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate (473720-84-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenyl phosphite; pyridine / 3 h / 70 °C

2: 1 h / 55 °C

With pyridine; triphenyl phosphite;

DOI:10.1016/j.bmcl.2007.03.106

upstream raw materials:

4-Ethoxyaniline

Boc-(R)-Ala

anthranilic acid

triphenyl phosphite

Downstream raw materials:

(R)-2-(1-Aminoethyl)-3-(4-ethoxyphenyl)-3H-quinazoline-4-one

C₂₄H₂₄N₄O₂

C₂₂H₂₇N₃O₃

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