methyl-[6-(2-methyl-5-nitro-phenyl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-2-yl]-amine

Base Information

Chemical Name:methyl-[6-(2-methyl-5-nitro-phenyl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-2-yl]-amine
CAS No.:1332329-58-4
Molecular Formula:C₁₅H₁₇N₅O₂
Molecular Weight:299.332
Hs Code.:

Synonyms:methyl-[6-(2-methyl-5-nitro-phenyl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-2-yl]-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl-[6-(2-methyl-5-nitro-phenyl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-2-yl]-amine

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Technology Process of methyl-[6-(2-methyl-5-nitro-phenyl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-2-yl]-amine

There total 5 articles about methyl-[6-(2-methyl-5-nitro-phenyl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-2-yl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.8%

: 471-29-4
1-methylguanidine

: 1332329-35-7
3-dimethylaminomethylene-1-(2-methyl-5-nitro-phenyl)-piperidin-4-one

: 1332329-58-4
methyl-[6-(2-methyl-5-nitro-phenyl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-2-yl]-amine

Guidance literature:: With sodium acetate; In ethanol; for 12h; Reflux;

Reference yield:

: 177-11-7
4,4-ethylenedioxy-piperidine

: 1332329-58-4
methyl-[6-(2-methyl-5-nitro-phenyl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-2-yl]-amine

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / Inert atmosphere; Reflux

2: water; sulfuric acid / tetrahydrofuran / 6 h / 60 °C

3: 12 h / Reflux

4: sodium acetate / ethanol / 12 h / Reflux

With sulfuric acid; water; sodium acetate; caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; toluene;

Reference yield:

: 7745-93-9
2-bromo-4-nitrotoluene

: 1332329-58-4
methyl-[6-(2-methyl-5-nitro-phenyl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-2-yl]-amine

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / Inert atmosphere; Reflux

2: water; sulfuric acid / tetrahydrofuran / 6 h / 60 °C

3: 12 h / Reflux

4: sodium acetate / ethanol / 12 h / Reflux

With sulfuric acid; water; sodium acetate; caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; toluene;