4-(2-methoxy-3-methylphenyl)-5-methylhexanoic acide

Base Information

• Chemical Name: 4-(2-methoxy-3-methylphenyl)-5-methylhexanoic acide
• CAS No.: 128291-87-2
• Molecular Formula: C₁₅H₂₂O₃
• Molecular Weight: 250.338
• Mol file: 128291-87-2.mol

Synonyms:4-(2-methoxy-3-methylphenyl)-5-methylhexanoic acide

Chemical Property of 4-(2-methoxy-3-methylphenyl)-5-methylhexanoic acide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-methoxy-3-methylphenyl)-5-methylhexanoic acide

There total 12 articles about 4-(2-methoxy-3-methylphenyl)-5-methylhexanoic acide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.9%

4-(2-methoxy-3-methylphenyl)-5-methylhexanenitrile (128291-86-1) → 4-(2-methoxy-3-methylphenyl)-5-methylhexanoic acide (128291-87-2)

Guidance literature:

With potassium hydroxide; In ethanol; for 10h; Heating;

DOI:10.1246/bcsj.63.272

Reference yield:

2-methylphenyl 2-methylpropionate (36438-54-7) → 4-(2-methoxy-3-methylphenyl)-5-methylhexanoic acide (128291-87-2)

Guidance literature:

Multi-step reaction with 11 steps

1: 1.) AlCl₃, 2.) dil. HCl / 1.) CS₂, 2h reflux, 2.) 140 deg C, 4h

2: 93.2 percent / K₂CO₃ / acetone / 10 h / Heating

3: 98.3 percent / NaBH₄ / methanol / 2 h / Heating

4: 99.4 percent / hydriodic acid (d = 1.7) / 1 h / Ambient temperature

5: Na / dimethylformamide; toluene / 3 h / 70 °C

6: 37.8 percent / aq. NaOH / 5 h / Heating

7: 27.3 percent / concd. H₂SO₄ / acetic acid; H₂O / 4 h / Heating

8: 93.5 percent / LiAlH₄ / diethyl ether / 2 h / Heating

9: 95 percent / pyridine / 5 h / 0 °C

10: 96.3 percent / KI / dimethylformamide / 10 h / 60 °C

11: 83.9 percent / 85percent KOH / ethanol / 10 h / Heating

With pyridine; hydrogenchloride; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; aluminium trichloride; sulfuric acid; hydrogen iodide; sodium; potassium carbonate; potassium iodide; In methanol; diethyl ether; ethanol; water; acetic acid; N,N-dimethyl-formamide; acetone; toluene;

DOI:10.1246/bcsj.63.272

Reference yield:

2'-Hydroxy-3'-methylisobutyrophenone (128291-79-2) → 4-(2-methoxy-3-methylphenyl)-5-methylhexanoic acide (128291-87-2)

Guidance literature:

Multi-step reaction with 10 steps

1: 93.2 percent / K₂CO₃ / acetone / 10 h / Heating

2: 98.3 percent / NaBH₄ / methanol / 2 h / Heating

3: 99.4 percent / hydriodic acid (d = 1.7) / 1 h / Ambient temperature

4: Na / dimethylformamide; toluene / 3 h / 70 °C

5: 37.8 percent / aq. NaOH / 5 h / Heating

6: 27.3 percent / concd. H₂SO₄ / acetic acid; H₂O / 4 h / Heating

7: 93.5 percent / LiAlH₄ / diethyl ether / 2 h / Heating

8: 95 percent / pyridine / 5 h / 0 °C

9: 96.3 percent / KI / dimethylformamide / 10 h / 60 °C

10: 83.9 percent / 85percent KOH / ethanol / 10 h / Heating

With pyridine; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; sulfuric acid; hydrogen iodide; sodium; potassium carbonate; potassium iodide; In methanol; diethyl ether; ethanol; water; acetic acid; N,N-dimethyl-formamide; acetone; toluene;

DOI:10.1246/bcsj.63.272

upstream raw materials:

4-(2-methoxy-3-methylphenyl)-5-methylhexanenitrile

2'-Hydroxy-3'-methylisobutyrophenone

2-methylphenyl 2-methylpropionate

2'-methoxy-3'-methylisobutyrophenone

Downstream raw materials:

(+/-)-cis-5-hydroxycalamenene