5-(4-{[4,11-bis(tert-butoxycarbonyl)-8-(2,2,2-trichloroethoxycarbonyl)-1,4,8,11-tetraazacyclotetradecan-1-yl]carbonyl}benzyl)-13-(2,2,2-trichloroethoxycarbonyl)-1,9-dithia-5,13-diazacyclohexadecane

Base Information

Chemical Name:5-(4-{[4,11-bis(tert-butoxycarbonyl)-8-(2,2,2-trichloroethoxycarbonyl)-1,4,8,11-tetraazacyclotetradecan-1-yl]carbonyl}benzyl)-13-(2,2,2-trichloroethoxycarbonyl)-1,9-dithia-5,13-diazacyclohexadecane
CAS No.:890706-73-7
Molecular Formula:C₄₆H₇₂Cl₆N₆O₉S₂
Molecular Weight:1129.96
Hs Code.:

5-(4-{[4,11-bis(tert-butoxycarbonyl)-8-(2,2,2-trichloroethoxycarbonyl)-1,4,8,11-tetraazacyclotetradecan-1-yl]carbonyl}benzyl)-13-(2,2,2-trichloroethoxycarbonyl)-1,9-dithia-5,13-diazacyclohexadecane

Synonyms:5-(4-{[4,11-bis(tert-butoxycarbonyl)-8-(2,2,2-trichloroethoxycarbonyl)-1,4,8,11-tetraazacyclotetradecan-1-yl]carbonyl}benzyl)-13-(2,2,2-trichloroethoxycarbonyl)-1,9-dithia-5,13-diazacyclohexadecane

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Chemical Property of 5-(4-{[4,11-bis(tert-butoxycarbonyl)-8-(2,2,2-trichloroethoxycarbonyl)-1,4,8,11-tetraazacyclotetradecan-1-yl]carbonyl}benzyl)-13-(2,2,2-trichloroethoxycarbonyl)-1,9-dithia-5,13-diazacyclohexadecane

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Technology Process of 5-(4-{[4,11-bis(tert-butoxycarbonyl)-8-(2,2,2-trichloroethoxycarbonyl)-1,4,8,11-tetraazacyclotetradecan-1-yl]carbonyl}benzyl)-13-(2,2,2-trichloroethoxycarbonyl)-1,9-dithia-5,13-diazacyclohexadecane

There total 4 articles about 5-(4-{[4,11-bis(tert-butoxycarbonyl)-8-(2,2,2-trichloroethoxycarbonyl)-1,4,8,11-tetraazacyclotetradecan-1-yl]carbonyl}benzyl)-13-(2,2,2-trichloroethoxycarbonyl)-1,9-dithia-5,13-diazacyclohexadecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 890706-71-5
1,8-bis(tert-butoxycarbonyl)-4-[4-(chloromethyl)benzoyl]-11-(2,2,2-trichloroethoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

: 180966-00-1
5-(2,2,2-trichloroethoxycarbonyl)-1,9-dithia-5,13-diazacyclohexadecane

: 890706-73-7
5-(4-{[4,11-bis(tert-butoxycarbonyl)-8-(2,2,2-trichloroethoxycarbonyl)-1,4,8,11-tetraazacyclotetradecan-1-yl]carbonyl}benzyl)-13-(2,2,2-trichloroethoxycarbonyl)-1,9-dithia-5,13-diazacyclohexadecane

Guidance literature:: With sodium carbonate; sodium iodide; In acetonitrile; for 24h; Heating;
DOI:10.1016/j.tet.2006.02.012

Reference yield:

: 866414-15-5
1,8-dibenzyl-4,11-bis(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

: 890706-73-7
5-(4-{[4,11-bis(tert-butoxycarbonyl)-8-(2,2,2-trichloroethoxycarbonyl)-1,4,8,11-tetraazacyclotetradecan-1-yl]carbonyl}benzyl)-13-(2,2,2-trichloroethoxycarbonyl)-1,9-dithia-5,13-diazacyclohexadecane

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / glacial acetic acid; hydrogen / palladium on charcoal / methanol / 12 h / 2280 Torr

2: 72 percent / triethylamine / CH₂Cl₂ / 12 h / 20 °C

3: 95 percent / triethylamine / CH₂Cl₂ / 12 h / 20 °C

4: 84 percent / sodium carbonate; sodium iodide / acetonitrile / 24 h / Heating

With hydrogen; sodium carbonate; acetic acid; triethylamine; sodium iodide; palladium on activated charcoal; In methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2006.02.012

Reference yield:

: 890706-67-9
1,8-bis(tert-butoxycarbonyl)-4-(2,2,2-trichloroethoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

: 890706-73-7
5-(4-{[4,11-bis(tert-butoxycarbonyl)-8-(2,2,2-trichloroethoxycarbonyl)-1,4,8,11-tetraazacyclotetradecan-1-yl]carbonyl}benzyl)-13-(2,2,2-trichloroethoxycarbonyl)-1,9-dithia-5,13-diazacyclohexadecane

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / triethylamine / CH₂Cl₂ / 12 h / 20 °C

2: 84 percent / sodium carbonate; sodium iodide / acetonitrile / 24 h / Heating

With sodium carbonate; triethylamine; sodium iodide; In dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2006.02.012