1-Cyano-3-[4-((E)-2-cyano-2-ethoxycarbonyl-vinyl)-phenyl]-2-pyridin-2-yl-4-[4-((E)-2-pyridin-2-yl-vinyl)-phenyl]-cyclobutanecarboxylic acid ethyl ester

Base Information

• Chemical Name: 1-Cyano-3-[4-((E)-2-cyano-2-ethoxycarbonyl-vinyl)-phenyl]-2-pyridin-2-yl-4-[4-((E)-2-pyridin-2-yl-vinyl)-phenyl]-cyclobutanecarboxylic acid ethyl ester
• CAS No.: 135413-75-1
• Molecular Formula: C₃₈H₃₂N₄O₄
• Molecular Weight: 608.696
• Mol file: 135413-75-1.mol

Synonyms:1-Cyano-3-[4-((E)-2-cyano-2-ethoxycarbonyl-vinyl)-phenyl]-2-pyridin-2-yl-4-[4-((E)-2-pyridin-2-yl-vinyl)-phenyl]-cyclobutanecarboxylic acid ethyl ester

Chemical Property of 1-Cyano-3-[4-((E)-2-cyano-2-ethoxycarbonyl-vinyl)-phenyl]-2-pyridin-2-yl-4-[4-((E)-2-pyridin-2-yl-vinyl)-phenyl]-cyclobutanecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Cyano-3-[4-((E)-2-cyano-2-ethoxycarbonyl-vinyl)-phenyl]-2-pyridin-2-yl-4-[4-((E)-2-pyridin-2-yl-vinyl)-phenyl]-cyclobutanecarboxylic acid ethyl ester

There total 5 articles about 1-Cyano-3-[4-((E)-2-cyano-2-ethoxycarbonyl-vinyl)-phenyl]-2-pyridin-2-yl-4-[4-((E)-2-pyridin-2-yl-vinyl)-phenyl]-cyclobutanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 1-cyano-3-<4-(2-cyano-2-methoxycarbonylethenyl)phenyl>-2-(2-pyridyl)-4-<4-<2-(2-pyridyl)ethenyl>phenyl>cyclobutanecarboxylate (135413-74-0) → 1-Cyano-3-[4-((E)-2-cyano-2-ethoxycarbonyl-vinyl)-phenyl]-2-pyridin-2-yl-4-[4-((E)-2-pyridin-2-yl-vinyl)-phenyl]-cyclobutanecarboxylic acid ethyl ester (135413-75-1)

Guidance literature:

for 3h; Irradiation;

Reference yield:

2-<2-(4-formylphenyl)ethenyl>pyridine (135310-65-5) → 1-Cyano-3-[4-((E)-2-cyano-2-ethoxycarbonyl-vinyl)-phenyl]-2-pyridin-2-yl-4-[4-((E)-2-pyridin-2-yl-vinyl)-phenyl]-cyclobutanecarboxylic acid ethyl ester (135413-75-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / piperidine / methanol / 1 h / 64 °C

2: 100 percent / 2 h / 2 °C / Irradiation

3: 100 percent / 3 h / Irradiation

With piperidine; In methanol;

Reference yield:

ethyl α-cyano-4-<2-(2-pyridyl)ethenyl>cinnamate (124067-51-2) → 1-Cyano-3-[4-((E)-2-cyano-2-ethoxycarbonyl-vinyl)-phenyl]-2-pyridin-2-yl-4-[4-((E)-2-pyridin-2-yl-vinyl)-phenyl]-cyclobutanecarboxylic acid ethyl ester (135413-75-1)

Guidance literature:

With NIKKOL TL-10FF; In various solvent(s); at -40 ℃; for 15h; Yield given; Irradiation; with filter;

DOI:10.1246/cl.1999.641

upstream raw materials:

ethyl α-cyano-4-<2-(2-pyridyl)ethenyl>cinnamate

methyl 1-cyano-3-<4-(2-cyano-2-methoxycarbonylethenyl)phenyl>-2-(2-pyridyl)-4-<4-<2-(2-pyridyl)ethenyl>phenyl>cyclobutanecarboxylate

2-<2-(4-formylphenyl)ethenyl>pyridine

methyl α-cyano-4-<2-(2-pyridyl)ethenyl>cinnamate

Downstream raw materials:

C₇₆H₆₄N₈O₈