(2S,4S,6S)-(-)-2-(3,4-dimethoxyphenyl)-6-(4-hydroxybutyl)-piperidin-4-ol

Base Information

• Chemical Name: (2S,4S,6S)-(-)-2-(3,4-dimethoxyphenyl)-6-(4-hydroxybutyl)-piperidin-4-ol
• CAS No.: 263247-25-2
• Molecular Formula: C₁₇H₂₇NO₄
• Molecular Weight: 309.406

Synonyms:(2S,4S,6S)-(-)-2-(3,4-dimethoxyphenyl)-6-(4-hydroxybutyl)-piperidin-4-ol

Chemical Property of (2S,4S,6S)-(-)-2-(3,4-dimethoxyphenyl)-6-(4-hydroxybutyl)-piperidin-4-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,4S,6S)-(-)-2-(3,4-dimethoxyphenyl)-6-(4-hydroxybutyl)-piperidin-4-ol

There total 21 articles about (2S,4S,6S)-(-)-2-(3,4-dimethoxyphenyl)-6-(4-hydroxybutyl)-piperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(2S,4S,6S)-2-(3,4-Dimethoxy-phenyl)-6-[4-(2-methoxy-ethoxymethoxy)-butyl]-piperidin-4-ol (263247-23-0) → (2S,4S,6S)-(-)-2-(3,4-dimethoxyphenyl)-6-(4-hydroxybutyl)-piperidin-4-ol (263247-25-2)

Guidance literature:

With sulfuric acid; In tetrahydrofuran;

DOI:10.3987/com-99-s82

Reference yield: 90.0%

(2S,4S,6S)-(-)-2-(4-benzyloxy-butyl)-6-(3,4-dimethoxy-phenyl)-piperidin-4-ol (299210-05-2) → (2S,4S,6S)-(-)-2-(3,4-dimethoxyphenyl)-6-(4-hydroxybutyl)-piperidin-4-ol (263247-25-2)

Guidance literature:

With hydrogen; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; at 20 ℃; for 8h;

DOI:10.1021/ol0061438

Reference yield: 76.0%

4-((4S,6S)-4-(tert-butyldimethylsilyloxy)-6-(3,4-dimethoxyphenyl)piperidin-2-yl)butan-1-ol (1191090-83-1) → (2S,4S,6S)-(-)-2-(3,4-dimethoxyphenyl)-6-(4-hydroxybutyl)-piperidin-4-ol (263247-25-2)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 6h;

DOI:10.1016/j.tetlet.2009.07.128

upstream raw materials:

(2S,4S,6S)-2-(3,4-Dimethoxy-phenyl)-6-[4-(2-methoxy-ethoxymethoxy)-butyl]-piperidin-4-ol

(2S,4S,6S)-(-)-2-(4-benzyloxy-butyl)-6-(3,4-dimethoxy-phenyl)-piperidin-4-ol

(R_S,S)-(-)-methyl-N-(p-toluenesulfinyl)-3-amino-3-(3,4-dimethoxyphenyl)propanoate

3,4-dimethoxy-benzaldehyde

Downstream raw materials:

(-)-(2S,4S,9aS)-2-hydroxy-4-(3,4-dimethoxyphenyl)-decahydroquinolizidine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 263247-25-2 (2S,4S,6S)-(-)-2-(3,4-dimethoxyphenyl)-6-(4-hydroxybutyl)-piperidin-4-ol

Send

Send

Metric Ton KG G Pound L ML

Send

Send