(5R,7R,8R,9S,10S)-8,9,10-tris(benzyloxy)-7-(benzyloxymethyl)-6-oxa-1-azaspiro[4.5]decan-2-one

Base Information

Chemical Name:(5R,7R,8R,9S,10S)-8,9,10-tris(benzyloxy)-7-(benzyloxymethyl)-6-oxa-1-azaspiro[4.5]decan-2-one
CAS No.:1226983-62-5
Molecular Formula:C₃₇H₃₉NO₆
Molecular Weight:593.72
Hs Code.:

Synonyms:(5R,7R,8R,9S,10S)-8,9,10-tris(benzyloxy)-7-(benzyloxymethyl)-6-oxa-1-azaspiro[4.5]decan-2-one

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Chemical Property of (5R,7R,8R,9S,10S)-8,9,10-tris(benzyloxy)-7-(benzyloxymethyl)-6-oxa-1-azaspiro[4.5]decan-2-one

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Technology Process of (5R,7R,8R,9S,10S)-8,9,10-tris(benzyloxy)-7-(benzyloxymethyl)-6-oxa-1-azaspiro[4.5]decan-2-one

There total 3 articles about (5R,7R,8R,9S,10S)-8,9,10-tris(benzyloxy)-7-(benzyloxymethyl)-6-oxa-1-azaspiro[4.5]decan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1226983-55-6
methyl 3-((2S,3S,4S,5R,6R)-2-azido-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)propanoate

: 1226983-62-5
(5R,7R,8R,9S,10S)-8,9,10-tris(benzyloxy)-7-(benzyloxymethyl)-6-oxa-1-azaspiro[4.5]decan-2-one

: 1226983-61-4
(5S,7R,8R,9S,10S)-8,9,10-tris(benzyloxy)-7-(benzyloxymethyl)-6-oxa-1-azaspiro[4.5]decan-2-one

Guidance literature:: With 5% Pd-CaCO3; hydrogen; In ethanol; at 20 ℃; for 2h; under 760.051 Torr;
DOI:10.1016/j.tetlet.2010.03.003

Reference yield:

: 1270942-55-6
C₃₈H₄₁NO₉

: 1226983-62-5
(5R,7R,8R,9S,10S)-8,9,10-tris(benzyloxy)-7-(benzyloxymethyl)-6-oxa-1-azaspiro[4.5]decan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: trimethylsilyl trifluoromethanesulfonate; trimethylsilylazide / dichloromethane / 0 - 20 °C

2: 5% Pd-CaCO3; hydrogen / ethanol / 2 h / 20 °C / 760.05 Torr

With trimethylsilyl trifluoromethanesulfonate; trimethylsilylazide; 5% Pd-CaCO3; hydrogen; In ethanol; dichloromethane;
DOI:10.1039/c0ob00555j

Reference yield:

: 89064-72-2
2,3,4,6-Tetra-O-benzyl-1-desoxy-1-nitro-D-mannopyranose

: 1226983-62-5
(5R,7R,8R,9S,10S)-8,9,10-tris(benzyloxy)-7-(benzyloxymethyl)-6-oxa-1-azaspiro[4.5]decan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / 0.5 h / 0 °C

2: trimethylsilyl trifluoromethanesulfonate; trimethylsilylazide / dichloromethane / 0 - 20 °C

3: 5% Pd-CaCO3; hydrogen / ethanol / 2 h / 20 °C / 760.05 Torr

With trimethylsilyl trifluoromethanesulfonate; trimethylsilylazide; 5% Pd-CaCO3; tetrabutyl ammonium fluoride; hydrogen; In ethanol; dichloromethane;
DOI:10.1039/c0ob00555j