3-methyl-4-(phenylsulfonyl)aniline

Base Information

• Chemical Name: 3-methyl-4-(phenylsulfonyl)aniline
• CAS No.: 7018-99-7
• Molecular Formula: C₁₃H₁₃NO₂S
• Molecular Weight: 247.318
• Mol file: 7018-99-7.mol

Synonyms:3-methyl-4-(phenylsulfonyl)aniline

Chemical Property of 3-methyl-4-(phenylsulfonyl)aniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methyl-4-(phenylsulfonyl)aniline

There total 5 articles about 3-methyl-4-(phenylsulfonyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-bromo-2-methyl-1-(phenylsulfonyl)benzene (5324-75-4) → 3-methyl-4-(phenylsulfonyl)aniline (7018-99-7)

Guidance literature:

With copper(I) oxide; ammonium hydroxide; In dimethyl sulfoxide; at 90 ℃; for 24h; Sealed tube;

DOI:10.1021/acs.orglett.8b03957

Reference yield: 88.0%

2-methyl-4-nitrodiphenyl sulfone (183723-74-2) → 3-methyl-4-(phenylsulfonyl)aniline (7018-99-7)

Guidance literature:

With tin(ll) chloride; In ethanol; for 1h; Heating;

DOI:10.1021/jm960365n

Reference yield:

Diphenyliodonium triflate (66003-76-7) → 3-methyl-4-(phenylsulfonyl)aniline (7018-99-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,3-bis(2,6-di-i-propylphenyl)ylidene gold chloride; potassium disulphite; sodium carbonate / acetonitrile / 24 h / 120 °C / Inert atmosphere; Schlenk technique

2: copper(I) oxide; ammonium hydroxide / dimethyl sulfoxide / 24 h / 90 °C / Sealed tube

With copper(I) oxide; potassium disulphite; ammonium hydroxide; 1,3-bis(2,6-di-i-propylphenyl)ylidene gold chloride; sodium carbonate; In dimethyl sulfoxide; acetonitrile;

DOI:10.1021/acs.orglett.8b03957

upstream raw materials:

2-methyl-4-nitrodiphenyl sulfone

4-bromo-2-methyl-1-(phenylsulfonyl)benzene

Diphenyliodonium triflate

(4-bromo-2-methylphenyl)boronic acid

Downstream raw materials:

4-{5-[(4-benzenesulfonyl-3-methyl-phenylamino)-methyl]-2-methyl-imidazol-1-ylmethyl}-benzonitrile

3-Methyl-4-phenylsulfonyl-trifluormethansulfonanilid