Technology Process of pyridin-3-ylmethyl {4-[({4-[(tert-butoxycarbonyl)amino]-1-phenyl-1H-pyrazol-3-yl}amino)carbonyl]benzyl}carbamate
There total 5 articles about pyridin-3-ylmethyl {4-[({4-[(tert-butoxycarbonyl)amino]-1-phenyl-1H-pyrazol-3-yl}amino)carbonyl]benzyl}carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
(benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N,N-diethyl-N-isopropylamine;
In
dichloromethane;
at 60 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: pyridine / copper diacetate / dichloromethane / 48 h / 20 °C
2.1: potassium hydroxide; water / tetrahydrofuran / 16 h / 20 °C
3.1: triethylamine; diphenylphosphoryl azide / 1,3-dioxane; tert-butyl alcohol / 16 h / Heating / reflux
3.2: 16 h / 20 °C
4.1: triethylamine; hydrogen / platinum(IV) oxide / methanol / 2 h / 20 °C
5.1: N,N-diethyl-N-isopropylamine; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane / 1 h / 60 °C
With
pyridine; potassium hydroxide; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diphenylphosphoryl azide; N,N-diethyl-N-isopropylamine; water; hydrogen; triethylamine;
platinum(IV) oxide; copper diacetate;
In
tetrahydrofuran; 1,3-dioxane; methanol; dichloromethane; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium hydroxide; water / tetrahydrofuran / 16 h / 20 °C
2.1: triethylamine; diphenylphosphoryl azide / 1,3-dioxane; tert-butyl alcohol / 16 h / Heating / reflux
2.2: 16 h / 20 °C
3.1: triethylamine; hydrogen / platinum(IV) oxide / methanol / 2 h / 20 °C
4.1: N,N-diethyl-N-isopropylamine; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane / 1 h / 60 °C
With
potassium hydroxide; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diphenylphosphoryl azide; N,N-diethyl-N-isopropylamine; water; hydrogen; triethylamine;
platinum(IV) oxide;
In
tetrahydrofuran; 1,3-dioxane; methanol; dichloromethane; tert-butyl alcohol;