O-ethyl S-<2-(p-methylphenyl)ethyl-2-oximino> dithiocarbonate

Base Information

• Chemical Name: O-ethyl S-<2-(p-methylphenyl)ethyl-2-oximino> dithiocarbonate
• CAS No.: 220222-20-8
• Molecular Formula: C₁₂H₁₅NO₂S₂
• Molecular Weight: 269.389
• Mol file: 220222-20-8.mol

Synonyms:O-ethyl S-<2-(p-methylphenyl)ethyl-2-oximino> dithiocarbonate

Chemical Property of O-ethyl S-<2-(p-methylphenyl)ethyl-2-oximino> dithiocarbonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-ethyl S-<2-(p-methylphenyl)ethyl-2-oximino> dithiocarbonate

There total 2 articles about O-ethyl S-<2-(p-methylphenyl)ethyl-2-oximino> dithiocarbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-bromo-1-(p-tolyl)ethane-1-one oxime (14181-74-9) + potassium ethyl xanthogenate (140-89-6) → O-ethyl S-<2-(p-methylphenyl)ethyl-2-oximino> dithiocarbonate (220222-20-8)

Guidance literature:

In acetone; at 20 ℃; for 6h;

DOI:10.1002/(sici)1099-0690(199901)1999:1<97::aid-ejoc97>3.0.co;2-k

Reference yield:

para-methylacetophenone (122-00-9) → O-ethyl S-<2-(p-methylphenyl)ethyl-2-oximino> dithiocarbonate (220222-20-8)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid; hydrogen bromide; bromine / 2.25 h / 15 - 25 °C

2: hydroxylamine hydrochloride / ethanol; water / 24 h / 20 °C

3: acetone / 3.5 h / 20 °C

With hydroxylamine hydrochloride; hydrogen bromide; bromine; acetic acid; In ethanol; water; acetone;

DOI:10.15227/orgsyn.079.0228

Reference yield: 74.0%

O-ethyl S-<2-(p-methylphenyl)ethyl-2-oximino> dithiocarbonate (220222-20-8) → N-hydroxy-4-(p-methylphenyl)thiazole-2(3H)-thione (220222-19-5)

Guidance literature:

With zinc(II) chloride; In diethyl ether; at 20 ℃; for 14h;

DOI:10.1002/(sici)1099-0690(199901)1999:1<97::aid-ejoc97>3.0.co;2-k DOI:10.1002/(SICI)1099-0690(199906)1999:6<1275::AID-EJOC1275>3.0.CO;2-2

upstream raw materials:

2-bromo-1-(p-tolyl)ethane-1-one oxime

potassium ethyl xanthogenate

para-methylacetophenone

Downstream raw materials:

N-hydroxy-4-(p-methylphenyl)thiazole-2(3H)-thione

3-Isopropoxy-4-p-tolyl-3H-thiazole-2-thione