N-((1R,2S,3R)-2,3-Bis-benzyloxy-1-benzyloxymethyl-pent-4-enyl)-2,2,2-trifluoro-acetamide

Base Information

Chemical Name:N-((1R,2S,3R)-2,3-Bis-benzyloxy-1-benzyloxymethyl-pent-4-enyl)-2,2,2-trifluoro-acetamide
CAS No.:397242-78-3
Molecular Formula:C₂₉H₃₀F₃NO₄
Molecular Weight:513.557
Hs Code.:

Synonyms:N-((1R,2S,3R)-2,3-Bis-benzyloxy-1-benzyloxymethyl-pent-4-enyl)-2,2,2-trifluoro-acetamide

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Chemical Property of N-((1R,2S,3R)-2,3-Bis-benzyloxy-1-benzyloxymethyl-pent-4-enyl)-2,2,2-trifluoro-acetamide

Chemical Property:

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Technology Process of N-((1R,2S,3R)-2,3-Bis-benzyloxy-1-benzyloxymethyl-pent-4-enyl)-2,2,2-trifluoro-acetamide

There total 2 articles about N-((1R,2S,3R)-2,3-Bis-benzyloxy-1-benzyloxymethyl-pent-4-enyl)-2,2,2-trifluoro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-((2S,3R)-2,3-Bis-benzyloxy-1-benzyloxymethyl-pent-4-enyl)-isoindole-1,3-dione

: 397242-78-3
N-((1R,2S,3R)-2,3-Bis-benzyloxy-1-benzyloxymethyl-pent-4-enyl)-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 1.5 h / Heating

2: triethylamine / 2 h / 0 - 20 °C

With hydrazine hydrate; In ethanol; triethylamine;
DOI:10.1016/S0040-4039(01)01684-7

Reference yield:

: 407-25-0
trifluoroacetic anhydride

: (1R,2S,3R)-2,3-Bis-benzyloxy-1-benzyloxymethyl-pent-4-enylamine

: 397242-78-3
N-((1R,2S,3R)-2,3-Bis-benzyloxy-1-benzyloxymethyl-pent-4-enyl)-2,2,2-trifluoro-acetamide

Guidance literature:: In triethylamine; at 0 - 20 ℃; for 2h;
DOI:10.1016/S0040-4039(01)01684-7

Reference yield:

: 397242-78-3
N-((1R,2S,3R)-2,3-Bis-benzyloxy-1-benzyloxymethyl-pent-4-enyl)-2,2,2-trifluoro-acetamide

: (2R,3R,4R,5S)-3,4-Bis-benzyloxy-2-benzyloxymethyl-5-(dimethoxy-phosphorylmethyl)-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: NMO; OsO₄ / tetrahydrofuran; acetone; H₂O / 48 h / 20 °C

2: NaIO₄ / tetrahydrofuran; acetone; H₂O / 1.5 h / 20 °C

3: 86 percent / LiOH / tetrahydrofuran; methanol; H₂O / 2 h / 20 °C

4: 69 percent / BF₃*OEt₂ / tetrahydrofuran / 2 h / -78 - 20 °C

5: 46 percent / Na₂CO₃ / CH₂Cl₂; H₂O / 1.5 h / 20 °C

6: 80 percent / triphenyltin hydride / toluene / 16 h / 110 °C

With lithium hydroxide; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; boron trifluoride diethyl etherate; triphenylstannane; sodium carbonate; In tetrahydrofuran; methanol; dichloromethane; water; acetone; toluene;
DOI:10.1016/S0040-4039(01)01684-7