3-(4-hydroxyphenyl)-6-isopentenyl-7-methoxy-4H-chromen-4-one

Base Information

• Chemical Name: 3-(4-hydroxyphenyl)-6-isopentenyl-7-methoxy-4H-chromen-4-one
• CAS No.: 1348361-30-7
• Molecular Formula: C₂₁H₂₀O₄
• Molecular Weight: 336.387
• Mol file: 1348361-30-7.mol

Synonyms:3-(4-hydroxyphenyl)-6-isopentenyl-7-methoxy-4H-chromen-4-one

Chemical Property of 3-(4-hydroxyphenyl)-6-isopentenyl-7-methoxy-4H-chromen-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-hydroxyphenyl)-6-isopentenyl-7-methoxy-4H-chromen-4-one

There total 5 articles about 3-(4-hydroxyphenyl)-6-isopentenyl-7-methoxy-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(p-hydroxyphenyl)boronic acid (71597-85-8) + 3-iodo-7-methoxy-6-isopentenyl-4Hchromen-4-one → 3-(4-hydroxyphenyl)-6-isopentenyl-7-methoxy-4H-chromen-4-one (1348361-30-7)

Guidance literature:

With palladium diacetate; sodium carbonate; at 50 ℃; for 2h;

DOI:10.1007/s00044-018-2197-6

Reference yield:

1-(2-hydroxy-4-methoxyphenyl)ethanone (552-41-0) → 3-(4-hydroxyphenyl)-6-isopentenyl-7-methoxy-4H-chromen-4-one (1348361-30-7)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate / ethyl acetate / 5 h / Reflux

2: 4 h / Inert atmosphere; Reflux

3: 15 h / Inert atmosphere; Reflux

4: iodine / methanol / 24 h / 20 °C

5: sodium carbonate; palladium diacetate / 2 h / 50 °C

With iodine; palladium diacetate; sodium carbonate; potassium carbonate; In methanol; ethyl acetate; 2: |Claisen Condensation / 5: |Suzuki Coupling;

DOI:10.1007/s00044-018-2197-6

Reference yield:

1-(4-methoxy-2-((3-methylbut-2-en-1-yl)oxy)phenyl)ethan-1-one (128961-25-1) → 3-(4-hydroxyphenyl)-6-isopentenyl-7-methoxy-4H-chromen-4-one (1348361-30-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 4 h / Inert atmosphere; Reflux

2: 15 h / Inert atmosphere; Reflux

3: iodine / methanol / 24 h / 20 °C

4: sodium carbonate; palladium diacetate / 2 h / 50 °C

With iodine; palladium diacetate; sodium carbonate; In methanol; 1: |Claisen Condensation / 4: |Suzuki Coupling;

DOI:10.1007/s00044-018-2197-6

upstream raw materials:

1-(2-hydroxy-4-methoxyphenyl)ethanone

1-(4-methoxy-2-((3-methylbut-2-en-1-yl)oxy)phenyl)ethan-1-one

2′-hydroxyl-4′-methoxyl-5′-isopentenylacetophenone

(p-hydroxyphenyl)boronic acid