2-[(R)-Bromo-((1R,7aS)-3-oxo-tetrahydro-pyrrolo[1,2-c]oxazol-1-yl)-methyl]-benzonitrile

Base Information

• Chemical Name: 2-[(R)-Bromo-((1R,7aS)-3-oxo-tetrahydro-pyrrolo[1,2-c]oxazol-1-yl)-methyl]-benzonitrile
• CAS No.: 84193-94-2
• Molecular Formula: C₁₄H₁₃BrN₂O₂
• Molecular Weight: 321.173
• Mol file: 84193-94-2.mol

Synonyms:2-[(R)-Bromo-((1R,7aS)-3-oxo-tetrahydro-pyrrolo[1,2-c]oxazol-1-yl)-methyl]-benzonitrile

Chemical Property of 2-[(R)-Bromo-((1R,7aS)-3-oxo-tetrahydro-pyrrolo[1,2-c]oxazol-1-yl)-methyl]-benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-[(R)-Bromo-((1R,7aS)-3-oxo-tetrahydro-pyrrolo[1,2-c]oxazol-1-yl)-methyl]-benzonitrile

There total 2 articles about 2-[(R)-Bromo-((1R,7aS)-3-oxo-tetrahydro-pyrrolo[1,2-c]oxazol-1-yl)-methyl]-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-L-Pro-H (69610-41-9,117625-90-8) → 2-[(R)-Bromo-((1R,7aS)-3-oxo-tetrahydro-pyrrolo[1,2-c]oxazol-1-yl)-methyl]-benzonitrile (84193-94-2)

Guidance literature:

Multi-step reaction with 2 steps

2: bromonium dicollidine perchlorate / CH₂Cl₂ / Heating

With bromonium dicollidine perchlorate; In dichloromethane;

DOI:10.1021/ja00341a073

Reference yield:

(S)-2-[(Z)-2-(2-Cyano-phenyl)-vinyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (84193-88-4,84193-89-5) → 2-[(R)-Bromo-((1R,7aS)-3-oxo-tetrahydro-pyrrolo[1,2-c]oxazol-1-yl)-methyl]-benzonitrile (84193-94-2) + 2-((3S,4S,4aS)-4-Bromo-1-oxo-hexahydro-pyrrolo[1,2-c][1,3]oxazin-3-yl)-benzonitrile (84193-93-1,84275-42-3)

Guidance literature:

With bromonium dicollidine perchlorate; In dichloromethane; Yield given. Yields of byproduct given; Heating;

DOI:10.1021/ja00341a073

upstream raw materials:

(S)-2-[(Z)-2-(2-Cyano-phenyl)-vinyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Boc-L-Pro-H