(8S,8aR)-8-benzoyloxy-1-hydroxy-1,2,3,7,8,8a-hexahydro-6H-indolizin-5-one

Base Information

Chemical Name:(8S,8aR)-8-benzoyloxy-1-hydroxy-1,2,3,7,8,8a-hexahydro-6H-indolizin-5-one
CAS No.:1273550-77-8
Molecular Formula:C₁₅H₁₇NO₄
Molecular Weight:275.304
Hs Code.:

Synonyms:(8S,8aR)-8-benzoyloxy-1-hydroxy-1,2,3,7,8,8a-hexahydro-6H-indolizin-5-one

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Chemical Property of (8S,8aR)-8-benzoyloxy-1-hydroxy-1,2,3,7,8,8a-hexahydro-6H-indolizin-5-one

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Technology Process of (8S,8aR)-8-benzoyloxy-1-hydroxy-1,2,3,7,8,8a-hexahydro-6H-indolizin-5-one

There total 1 articles about (8S,8aR)-8-benzoyloxy-1-hydroxy-1,2,3,7,8,8a-hexahydro-6H-indolizin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₂₅NO₄Si

: 1273550-77-8
(8S,8aR)-8-benzoyloxy-1-hydroxy-1,2,3,7,8,8a-hexahydro-6H-indolizin-5-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.583333h; Inert atmosphere;
DOI:10.1016/j.tet.2010.12.048

Reference yield: 73.0%

: 1273550-77-8
(8S,8aR)-8-benzoyloxy-1-hydroxy-1,2,3,7,8,8a-hexahydro-6H-indolizin-5-one

: 1273550-69-8
(+)-(8S,8aR)-8-benzoyloxy-3,7,8,8a-tetrahydro-6H-indolizin-5-one

Guidance literature:: With Martins sulfurane; In tetrahydrofuran; diethyl ether; at 20 ℃; Inert atmosphere; Cooling with ice;
DOI:10.1016/j.tet.2010.12.048

Reference yield:

: 1273550-77-8
(8S,8aR)-8-benzoyloxy-1-hydroxy-1,2,3,7,8,8a-hexahydro-6H-indolizin-5-one

: C₁₅H₁₇NO₅

Guidance literature:: Multi-step reaction with 2 steps

1: Martins sulfurane / tetrahydrofuran; diethyl ether / 20 °C / Inert atmosphere; Cooling with ice

2: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / acetone / 2 h / Inert atmosphere; Cooling with ice

With osmium(VIII) oxide; Martins sulfurane; water; 4-methylmorpholine N-oxide; In tetrahydrofuran; diethyl ether; acetone;
DOI:10.1016/j.tet.2010.12.048