3-[[3-[[4-chloro-2-[1-[3-fluoro-5-(trifluoromethyl)-2-pyridyl]pyrazole-4-carbonyl]phenyl]carbamoyl]phenyl]methylsulfanyl]propanoic acid

Base Information

Chemical Name:3-[[3-[[4-chloro-2-[1-[3-fluoro-5-(trifluoromethyl)-2-pyridyl]pyrazole-4-carbonyl]phenyl]carbamoyl]phenyl]methylsulfanyl]propanoic acid
CAS No.:1441144-24-6
Molecular Formula:C₂₇H₁₉ClF₄N₄O₄S
Molecular Weight:606.985
Hs Code.:

Synonyms:3-[[3-[[4-chloro-2-[1-[3-fluoro-5-(trifluoromethyl)-2-pyridyl]pyrazole-4-carbonyl]phenyl]carbamoyl]phenyl]methylsulfanyl]propanoic acid

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Chemical Property of 3-[[3-[[4-chloro-2-[1-[3-fluoro-5-(trifluoromethyl)-2-pyridyl]pyrazole-4-carbonyl]phenyl]carbamoyl]phenyl]methylsulfanyl]propanoic acid

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Technology Process of 3-[[3-[[4-chloro-2-[1-[3-fluoro-5-(trifluoromethyl)-2-pyridyl]pyrazole-4-carbonyl]phenyl]carbamoyl]phenyl]methylsulfanyl]propanoic acid

There total 6 articles about 3-[[3-[[4-chloro-2-[1-[3-fluoro-5-(trifluoromethyl)-2-pyridyl]pyrazole-4-carbonyl]phenyl]carbamoyl]phenyl]methylsulfanyl]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89402-29-9
2-bromo-3-fluoro-5-(trifluoromethyl)-pyridine

: 1441142-36-4
3-[[3-[[4-chloro-2-(1H-pyrazole-4-carbonyl)phenyl]carbamoyl]phenyl]methylsulfanyl]propanoic acid

: 1441144-24-6
3-[[3-[[4-chloro-2-[1-[3-fluoro-5-(trifluoromethyl)-2-pyridyl]pyrazole-4-carbonyl]phenyl]carbamoyl]phenyl]methylsulfanyl]propanoic acid

Guidance literature:: With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; caesium carbonate; In dimethyl sulfoxide; at 150 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 152493-32-8
(5-chloro-2-nitro-phenyl)-(1-tritylpyrazol-4-yl)methanone

: 1441144-24-6
3-[[3-[[4-chloro-2-[1-[3-fluoro-5-(trifluoromethyl)-2-pyridyl]pyrazole-4-carbonyl]phenyl]carbamoyl]phenyl]methylsulfanyl]propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: iron; acetic acid / ethanol; water / 1 h / 60 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h / 20 °C

3: potassium carbonate; N,N-dimethyl-formamide / 20 °C

4: trifluoroacetic acid / water / 60 °C

5: water; sodium hydroxide / ethanol / 4 h / 60 °C

6: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; caesium carbonate / dimethyl sulfoxide / 0.5 h / 150 °C / Microwave irradiation

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; water; iron; potassium carbonate; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; sodium hydroxide; In ethanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 153876-24-5
(2-amino-5-chloro-phenyl)-(1-tritylpyrazol-4-yl)methanone

: 1441144-24-6
3-[[3-[[4-chloro-2-[1-[3-fluoro-5-(trifluoromethyl)-2-pyridyl]pyrazole-4-carbonyl]phenyl]carbamoyl]phenyl]methylsulfanyl]propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h / 20 °C

2: potassium carbonate; N,N-dimethyl-formamide / 20 °C

3: trifluoroacetic acid / water / 60 °C

4: water; sodium hydroxide / ethanol / 4 h / 60 °C

5: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; caesium carbonate / dimethyl sulfoxide / 0.5 h / 150 °C / Microwave irradiation

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; water; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; sodium hydroxide; In ethanol; dichloromethane; water; dimethyl sulfoxide;